Analysis of Androgen Receptor Expression and Activity in the Mouse Brain

May 2024 in “ Scientific Reports ”

D. Alwyn Dart, Charlotte L. Bevan, Pinar Uysal‐Onganer, Wen G. Jiang

androgen receptor AR androgen deprivation therapy ADT ARE-Luc reporter mice immunohistochemical staining

Studysummary In this study, researchers examined androgen receptor activity in the adult mouse brain and found specific expression in key brain areas, which could inform understanding of cognitive side effects in humans undergoing androgen deprivation therapy for prostate cancer.

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research Visualizing Androgen Receptor Activity in Male and Female Mice

89 citations , August 2013 in “PloS one”

This study used the "ARE-Luc" mouse model to visualize androgen receptor activity across various tissues in both male and female mice, highlighting the direct action of androgens outside reproductive organs.