Androgen Affects Inhibitory Avoidance Memory by Primarily Acting on Androgen Receptor in the Brain in Adolescent Male Rats

February 2021 in “ Brain Sciences ”

Md Nabiul Islam, Yuya Sakimoto, Mir Rubayet Jahan, Emi Miyasato, Abu Md Mamun Tarif, Kanako Nozaki, Koh‐hei Masumoto, Akie Yanai, Dai Mitsushima, Koh Shinoda

androgens androgen receptors testosterone dihydrotestosterone AR-antagonist flutamide orchiectomy amygdala hippocampus AR DHT

TLDR Androgens improve memory in adolescent male rats by acting on brain receptors.

The study examined the effects of androgens on inhibitory avoidance memory in adolescent male rats, focusing on androgen receptor (AR) activity in the brain. It involved 72 rats divided into four groups, with 18 rats per group for serum analysis and 6 rats per group for behavioral and immunoreactivity assessments. Orchiectomy reduced memory retention and AR-immunoreactivity, while testosterone (T) or dihydrotestosterone (DHT) treatment restored these effects. The AR-antagonist flutamide mimicked orchiectomy effects, indicating that androgens enhanced memory by acting on ARs in the amygdala and hippocampus. The study concluded that androgens modulated memory by increasing AR expression and neuronal excitability, with further research needed to explore the pathways and potential sex differences in androgenic effects on memory.

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