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ODC1 gene mutations cause a neurodevelopmental disorder with large head size, hair loss, and facial abnormalities.

A new genetic disorder caused by an ODC1 mutation can be treated with DFMO.

Four new cases of Bachmann-Bupp syndrome suggest potential for targeted treatment.

DFMO treatment improves hair growth, muscle tone, and development in Bachmann-Bupp syndrome patients.

Ingenol mebutate gel changes gene expression related to skin development and immune response in actinic keratosis.

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

Zebrafish need MYC and FGF to regenerate inner ear hair cells.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.

Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.

Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.

Hair loss patients may have different polyamine levels in various scalp areas.

Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Finasteride helps reduce heart issues and improves heart function.

Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

Polyamines help fix DNA damage accurately in cells.

Adult esophageal cells can start to become like skin cells, with a key pathway influencing this change.

DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.

Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.

The commentary explains that a balance of HR protein and putrescine is important for normal hair growth.