64 citations
,
November 2012 in “EMBO reports” This review discusses the role of lamins in development, tissue maintenance, and stress response, and does not report new experimental findings.
34 citations
,
March 2007 in “Biochemical and Biophysical Research Communications” This study suggests that decreased expression of thioredoxin reductase 1 in hair follicle cells may contribute to glucocorticoid resistance in some alopecia areata patients by affecting the intracellular redox system.
31 citations
,
February 2007 in “Molecular Carcinogenesis” This study found that transgenic mice overexpressing human ATF3 showed hyperplastic and dysplastic changes in epithelial tissues, with a high incidence of oral cancer, suggesting potential oncogenic properties of ATF3.
25 citations
,
January 2012 in “Proteome Science” This study suggests that common proteomic changes, including the expression of the protein S100A6, may occur during the expansion of AD-MSC from different donors.
17 citations
,
March 2005 in “Journal of Investigative Dermatology” This study found that human hair follicle bulge stem cells exhibited autofluorescence, potentially due to high flavin- and NAD-related compound levels, highlighting the need to consider this when using fluorescent antibodies for studying these cells.
15 citations
,
February 2014 in “Journal of Investigative Dermatology” NF-κB activity is crucial for keeping hair in the growth phase.
14 citations
,
November 2007 in “Journal of Dermatological Science” This review discusses the roles of epithelial-mesenchymal interactions and dermal papilla in hair follicle growth and cycling, but it reports no new clinical results.
14 citations
,
September 2006 in “Experimental Dermatology” This study suggests that interleukin-1 α influences dermal papilla cell activity by modifying androgen receptor expression and increasing the secretion of several growth factors and cytokines.
11 citations
,
June 1974 in “Journal of Cutaneous Pathology” In this study, electron microscopy of follicular mucinosis showed severe cytoplasmic degeneration in hair follicles, with myelin figures and onion-like lamellar structures, but no indications of mucin release through degeneration or degradation were found.
8 citations
,
February 1968 in “Australian Journal of Zoology” This study describes the structure and composition of the epidermal horny layer in elephant seals, noting that its keratinized cells are attached without a specialized fission zone, differing from the sloughing mechanism in reptiles.
5 citations
,
March 2017 in “Molecular biology of the cell” This article summarizes discussions from a minisymposium on organelle contact sites, highlighting new insights into their roles in cellular processes, but reports no novel experimental results.
5 citations
,
October 2012 in “Australian veterinary journal” This report describes two South Australian Poll Hereford calves with a syndrome of congenital dyserythropoietic anaemia, dyskeratosis, and progressive alopecia, observing specific blood and bone marrow abnormalities.
5 citations
,
January 2005 in “PubMed” In this study, researchers observed that apoptosis occurs in both growing and regressing hair follicles in dogs, indicating a spatio-temporal relationship with the hair cycle.
2 citations
,
April 2019 in “Experimental Dermatology” This study observed that applying a pulling force to hair follicles led to significant compression of nuclei in certain cell layers and distinct collagen changes at different follicle depths.
2 citations
,
June 2013 in “Journal of Clinical Pathology” This article reviews the role of LMNA gene mutations, particularly in Hutchinson–Gilford progeria syndrome, but does not report new experimental findings.
2 citations
,
June 2001 in “Medical Electron Microscopy” This study observed that the keratinization pattern of trichilemmal cysts in two Japanese women may originate from the proliferation of the outer root sheath in the follicular isthmus of anagen hairs.
This article reviews current understanding of Hutchinson–Gilford Progeria Syndrome and suggests RNA-based treatments show promise, but no new clinical findings are reported.
December 2025 in “The Journal of Cell Biology” This study found that keratin 15 lacks the ability to sequester YAP1 in keratinocytes effectively, unlike keratin 14, and suggests that a higher K15:K14 ratio may promote a progenitor state and inhibit differentiation in epidermal keratinocytes.
March 2024 in “Research Square (Research Square)” This study found that a combined genotypic and phenotypic reanalysis increased molecular diagnostic accuracy from 9% to 26% in a cohort of unresolved monogenic diabetes cases, identifying five previously overlooked genetic defects.
This study demonstrated potential in using specific keratin peptide profiles from human hair shafts to distinguish gender and ethnicity, suggesting it could enhance forensic investigations, though larger studies are needed.
January 2016 in “UNESP Institutional Repository (São Paulo State University)” This study suggests that the phenotype of melasma in women is influenced by structural and cellular changes across the epidermal-melanin unit, not just melanocyte hypertrophy, highlighting potential roles for dermal damage repair and fibroblast senescence.
August 2015 in “Bangladesh Journal of Pharmacology” This study determined that the genome size of Eclipta alba is 4.27 billion base pairs and Aloe barbadensis is 4.42 billion base pairs, providing data for potential future research.
May 2014 in “Transfusion and Apheresis Science” The study found that the quality of cord blood units remains consistent before freezing and after thawing, indicating that attached tube segments reliably represent the graft's properties.
August 2013 in “Nature Reviews Drug Discovery” New treatments may restore cancer-blocking proteins, slow prostate cancer, identify drug targets, and potentially regrow hair.
August 2013 in “Nature Reviews Drug Discovery” New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.
June 2010 in “The Knowledge Bank (The Ohio State University)” This study found that inhibiting retinoic acid synthesis in mouse hair follicles allowed WNT signaling to remain active, suggesting potential implications for developing treatments for hair disorders and skin cancer.
January 2008 in “Vestnik Tomskogo gosudarstvennogo universiteta Filologiya” This study found that overexpressing thymosin beta-4 in transgenic cashmere goats could potentially increase cashmere yield by boosting the number of secondary hair follicles.
January 2006 in “Chieh P'ou Hsueh Pao” In this study, the researchers observed that transfecting hair follicle cells with an amino-terminal truncated beta-catenin gene significantly increased cell proliferation, potentially by enhancing c-myc gene expression.
266 citations
,
January 2016 in “Development” In this study, researchers found that YAP and TAZ, when localized in the nucleus of basal layer cells, are crucial for skin regeneration and hair growth, with their loss leading to slower cell proliferation, hair loss, and impaired wound healing in mice.
186 citations
,
December 2012 in “Current opinion in cell biology” This review discusses the recent advancements in understanding how keratins influence cytoarchitecture, cell dynamics, and disease processes but reports no new clinical results; the authors highlight its roles in development and diseases like cancer.