Studysummary In this study, researchers observed that apoptosis occurs in both growing and regressing hair follicles in dogs, indicating a spatio-temporal relationship with the hair cycle. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the role of apoptotic cell death in canine hair follicles, aiming to understand its relationship with the hair cycle in dogs. Apoptosis, characterized by cytoplasmic and nuclear condensation and DNA fragmentation, was observed in both growing and regressing follicle epithelium. The findings, assessed using TUNEL and histological assays, indicated that apoptosis was a key mechanism in hair follicle growth and regression, similar to observations in humans, mice, rats, and guinea pigs.
29 citations
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April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” This study found that ICAM-1 expression in murine skin is developmentally regulated and crucial for skin and hair follicle remodeling beyond its recognized role in immune responses.
1113 citations
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August 1999 in “The New England Journal of Medicine” This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.
140 citations
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December 1998 in “Journal of Investigative Dermatology” Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.
124 citations
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August 1994 in “Journal of Investigative Dermatology” This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.
