Effects of Retinoic Acid on Wingless (WNT) Signaling in the Hair Follicles of Mice

    June 2010 in “ The Knowledge Bank (The Ohio State University) ”
    Kelly M. Hodovanic
    Studysummary This study found that inhibiting retinoic acid synthesis in mouse hair follicles allowed WNT signaling to remain active, suggesting potential implications for developing treatments for hair disorders and skin cancer.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 17

    1. More Than One Way to Skin Genes & Development · 2008
    2. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    3. The Hair Cycle Journal of Cell Science · 2006
    4. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    5. Acne and Sebaceous Gland Function Clinics in dermatology · 2004
    6. Regulating the Regulators: Routing the Wnt-Beta-Catenin-Lef Signals Journal of Investigative Dermatology · 2004
    7. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    8. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    9. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    10. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    11. The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation American Journal Of Pathology · 1999
    12. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    13. Towards Defining the Pathogenesis of the Hairless Phenotype Journal of Investigative Dermatology · 1998
    14. Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles Differentiation · 1994
    15. Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    16. Catagen in the Hairless House Mouse American Journal of Anatomy · 1967
    17. Critical Stages of Hair Development and Pigmentation in the Mouse Physiological zoology · 1951

    Related research 1

    1. Immunolocalization of Proteins Related to Retinoic Acid Synthesis and Signaling During Hair Cycle 2009