Effects of Retinoic Acid on Wingless (WNT) Signaling in the Hair Follicles of Mice

June 2010 in “ The Knowledge Bank (The Ohio State University) ”

Kelly M. Hodovanic

retinoic acid WNT signaling hair follicles ß-catenin anagen citral disulfiram RA synthesis inhibitors ß-galactosidase antibody RA WNT beta-catenin

TLDR Inhibiting retinoic acid activates WNT signaling, potentially aiding hair disorder and skin cancer treatments.

The study investigated the effects of retinoic acid (RA) on WNT signaling in mouse hair follicles. It was found that nuclear ß-catenin, a marker of WNT signaling, peaked during mid-anagen, 6 days after hair cycle synchronization. The study tested citral and disulfiram as topical inhibitors of RA synthesis, finding that citral provided stronger inhibition of the RA target gene RAR-ß, although it did not completely inhibit RA synthesis. Inhibition of RA was associated with active WNT signaling. The study also identified ß-galactosidase antibody as a more efficient method for measuring WNT signaling than nuclear ß-catenin localization. These findings suggested that further research on RA and WNT interactions could influence treatments for hair diseases and skin cancer.

View this study on hdl.handle.net →

Discuss this study in the Community →

Research cited in this study

17 / 17 results

research More Than One Way to Skin

218 citations , April 2008 in “Genes & Development”

Skin stem cells help repair damage and maintain healthy skin.

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

48 citations , March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Retinoic acid production and signaling in hair follicles are regulated by location and timing, affecting hair growth and cycling.

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations , January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Acne and Sebaceous Gland Function

463 citations , September 2004 in “Clinics in dermatology”

Effective acne treatments should reduce sebum, bacteria, and inflammation, with isotretinoin being the best for severe cases.

research Regulating the Regulators: Routing the Wnt-Beta-Catenin-Lef Signals

5 citations , July 2004 in “Journal of Investigative Dermatology”

Understanding Wnt-β-catenin signaling is key to hair growth and could impact conditions like baldness.

research Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors

335 citations , March 2004 in “Development”

Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.

research Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin

555 citations , July 2001 in “Genes & Development”

Tcf3 and Lef1 are key in deciding skin stem cell roles.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

990 citations , October 1999 in “Development”

Activated LEF/TCF complexes are crucial for hair development and cycling.

research The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation

166 citations , July 1999 in “American Journal Of Pathology”

research WNT Signaling in the Control of Hair Growth and Structure

271 citations , March 1999 in “Developmental biology”

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

research Towards Defining the Pathogenesis of the Hairless Phenotype

86 citations , June 1998 in “Journal of Investigative Dermatology”

The hairless gene mutation causes baldness by disrupting hair follicle structure.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations , January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

research Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation

85 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

research Catagen in the Hairless House Mouse

17 citations , November 1967 in “American Journal of Anatomy”

Hairless mice have longer hair follicles and abnormal structures during the catagen phase.

research Critical Stages of Hair Development and Pigmentation in the Mouse

236 citations , January 1951 in “Physiological zoology”

Hair growth and pigmentation in mice involve specific stages crucial for research.

Related Research

1 / 1 results

research Immunolocalization of Proteins Related to Retinoic Acid Synthesis and Signaling During Hair Cycle

May 2009

Retinoic acid affects hair growth and can cause hair loss.