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Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

PNKP is essential for keeping adult mouse progenitor cells healthy and growing normally.

Blocking Rab27a slows hair growth, while blocking Rab27b encourages it.

The document explains the genetic causes and characteristics of inherited hair disorders.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

Finding functions for unknown GPCRs is hard but key for making new drugs.

The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.

The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Fat-related cells are important for initiating hair growth.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Auxin and ethylene hormones both work together and against each other to control plant growth.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.