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This study found that the transcription factor Lhx2 regulates Sonic Hedgehog signaling in mouse retinal progenitor cells, mainly by controlling the expression of co-receptors essential for effective pathway activation during early retinal neurogenesis.

This study found that miR-124 may facilitate the differentiation of hair follicle stem cells into neuronal cells by targeting Sox9 and Ptbp1.

This study found that the proteins GDNF, NTN, GFRα-1, GFRα-2, and c-Ret are differentially expressed during various stages of the human hair follicle cycle, with potential implications for hair biology.

This study suggests that the down-regulation of 14-3-3 proteins in wild-type keratinocytes, absent in Smad4 mutant keratinocytes, might contribute to the failure of hair follicles to initiate catagen in Smad4 knockout mice.

This study identified novel mutations in the DSG4 gene in a Japanese patient with monilethrix, affecting protein interactions that may disrupt hair shaft structure.

This study found that disrupting Sox21 in developing teeth leads to severe enamel hypoplasia, regional osteoporosis, and abnormal hair formation, with impaired dental epithelial differentiation and regulation of hair follicle cell fate.

This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.

This study found that PDCD4 protein expression is reduced in various skin cancers compared to normal skin, suggesting its potential role in preventing or treating certain skin cancers.

This study found that upregulation of NFIC may enhance proliferation and osteogenic/cementogenic differentiation in rat dental follicle cells.

In this study, β-catenin overexpression in human hair outer root sheath cells increased the expression of Pitx2, which activated the follicular differentiation pathway, suggesting Pitx2's potential role as a modulator in hair growth control.

This study reports that miR-302 promotes pluripotency by inhibiting NR2F2 and indirectly regulating OCT4 in stem cells, enhancing reprogramming efficiency when added to traditional factors.

This research found that nod factor can induce root hair reorientation and gene expression in Medicago truncatula with as little as a single molecule, implicating heterotrimeric G-protein signaling in this process.

This study found that lower GPX4 mRNA levels in polymorphonuclear neutrophils of systemic lupus erythematosus patients were negatively associated with disease activity and serological markers, suggesting a diagnostic value for GPX4 mRNA.

This study found that Foxp1, a transcriptional factor, plays a key role in regulating hair follicle stem cell proliferation by modulating oxidative stress and the cell cycle during hair growth phases.

This study identified a critical NF-κB-LHX2-TGFβ2 signaling pathway essential for primary hair follicle development in mice, revealing new insights into the underlying mechanisms of morphogenesis.

This review highlights the roles of key transcription factors and signaling pathways in regulating olfactory epithelium regeneration, discussing recent advances in single-cell and spatial transcriptomics as well as organoid models to enhance understanding of olfactory regeneration mechanisms.

This study reveals that CSPG4-positive basal cell keratinocytes show distinct global gene expression from CSPG4-negative cells, despite similar colony-forming efficiency.

This study found that misexpression of Hoxc8 in mice led to ectopic mammary development and suggests Hox genes may play crucial roles in the regional specification and initiation of cutaneous accessory organs.

In this report, researchers describe a 13-month-old with neurodevelopmental disorder NEDESBA, confirming a TRAPPC4 gene mutation as the cause after excluding biotinidase deficiency, highlighting the importance of molecular testing for accurate diagnosis in overlapping metabolic and genetic conditions.

This study found that the LEF-1 binding site acts as an enhancer element for the wool keratin intermediate filament gene promoter in hair follicle cortex, with specificity regulated by additional factors.

This study found that CTCF is crucial for proper skin and hair follicle development in mice, affecting keratinocyte differentiation and gene expression in keratin loci.

This study found that mouse skin CD4(+) memory T cells are in equilibrium with the circulation under steady state but increase in specific clusters in response to infection or inflammation.

In this study, researchers identified a specific DNA aptamer, Ap.OR2AT4.17, that effectively prolonged hair growth and increased hair shaft elongation in organ-cultured human hair follicles by targeting the olfactory receptor OR2AT4. This finding suggests the aptamer's potential as a novel therapy for hair loss disorders.

This study found that NFI-C plays a crucial role in the transition from the telogen to anagen phase of the hair follicle cycle, affecting hair growth initiation in mice.

Immune cells boost stem cell activity in hairy moles, causing more hair growth.

This study found that the expression of the protein SOX2 is associated with the potential for beige adipocyte formation and adipocyte plasticity in both human and mouse models.

In this study, high expression of S100A4 in glioblastoma was associated with worse patient survival and promoted tumor progression by enhancing pro-tumorigenic vascular functions.

The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.

In this study, researchers found that the expression of SLC1A6, a gene linked to calcium gradient and keratinocyte differentiation in the skin, significantly decreases with age, which may contribute to reduced skin barrier function in elderly individuals.