NFIC Promotes the Vitality and Osteogenic Differentiation of Rat Dental Follicle Cells

The study from August 20, 2019, demonstrated that Nuclear Factor I-C (NFIC) plays a significant role in the vitality and osteogenic/cementogenic differentiation of rat dental follicle cells (DFCs). The research showed that overexpression of NFIC in DFCs led to increased cell proliferation, higher alkaline phosphatase activity, and elevated mRNA levels of osteogenic markers, while NFIC silencing had the opposite effects, increasing apoptosis and downregulating osteogenic markers. These findings indicate that NFIC could be a target for enhancing periodontal tissue regeneration. The study included quantitative analyses with sample sizes ranging from n=3 to n=5 for various experiments, providing moderate evidence for the conclusions. The research was funded by the Guangdong Science and Technology Foundation of China.