NFIC Promotes the Vitality and Osteogenic Differentiation of Rat Dental Follicle Cells

    August 2019 in “ Journal of Molecular Histology ”
    Fuping Zhang, Min Liang, Cunyou Zhao, Yao‐Shi Fu, Shaojie Yu
    Image of study
    TLDR NFIC helps rat dental cells grow and turn into bone-like cells.
    The study from August 20, 2019, demonstrated that Nuclear Factor I-C (NFIC) plays a significant role in the vitality and osteogenic/cementogenic differentiation of rat dental follicle cells (DFCs). The research showed that overexpression of NFIC in DFCs led to increased cell proliferation, higher alkaline phosphatase activity, and elevated mRNA levels of osteogenic markers, while NFIC silencing had the opposite effects, increasing apoptosis and downregulating osteogenic markers. These findings indicate that NFIC could be a target for enhancing periodontal tissue regeneration. The study included quantitative analyses with sample sizes ranging from n=3 to n=5 for various experiments, providing moderate evidence for the conclusions. The research was funded by the Guangdong Science and Technology Foundation of China.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 309 results

      community First year progress: oral fin/topical min

      in Progress Pictures  408 upvotes 1 year ago
      Progress in hair loss recovery over the course of one year, using oral finasteride and topical minoxidil. Suggestions were made to try topical finasteride and minoxidil with microneedling, and other factors such as stress, iron, nutrition discussed.

      community I just made my own PRP - DIY PRP

      in Research/Science  548 upvotes 1 year ago
      The post and conversation are about a user who made their own Platelet-Rich Plasma (PRP) for hair loss treatment at home, using their own blood and a centrifuge. The responses vary, with some users supporting the DIY approach to save money, others expressing concern about the safety and effectiveness of the method, and a few joking about the lengths people will go to combat hair loss.

      community My story (22m, fin, min, niz, RU, dut –> part frontal hair system)

      in Finasteride/Dutasteride  19 upvotes 1 year ago
      User "hairplsrn" shares their hair loss journey, trying various treatments like finasteride, minoxidil, and dutasteride, but experiencing worsening hair loss. They decide to get a partial frontal hair system and continue medication, while others offer support and advice on staying on medication and focusing on overall confidence.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 7 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Similar Research

    5 / 1000+ results