Nuclear Factor I-C Promotes Proliferation and Differentiation of Apical Papilla-Derived Human Stem Cells In Vitro
March 2015
in “
Experimental Cell Research
”
TLDR NFIC helps human dental stem cells grow and become tooth-like cells.
In the 2015 study, researchers found that overexpression of Nuclear Factor I-C (NFIC) in stem cells from the apical papilla (SCAPs) led to increased cell proliferation, mineralization, and upregulation of odontogenic markers, suggesting NFIC's role in promoting osteo/odontoblastic differentiation. Conversely, NFIC knockdown inhibited these processes. These findings highlight NFIC's potential as a therapeutic target for dentin/root regeneration. The study was conducted in vitro and supported by statistical significance with a p-value of <0.05. Further in vivo experiments are needed to confirm these findings. The research received funding from the National Natural Science Foundation of China and other sources.
