Nuclear Factor I-C Promotes Proliferation and Differentiation of Apical Papilla-Derived Human Stem Cells In Vitro

    February 2015 in “ Experimental Cell Research ”
    Jing Zhang, Zhihua Wang, Yong Jiang, Ziru Niu, Linglin Fu, Zheng Luo, Paul R. Cooper, Anthony J. Smith, He Wang
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    TLDR NFIC helps human dental stem cells grow and become tooth-like cells.
    In the 2015 study, researchers found that overexpression of Nuclear Factor I-C (NFIC) in stem cells from the apical papilla (SCAPs) led to increased cell proliferation, mineralization, and upregulation of odontogenic markers, suggesting NFIC's role in promoting osteo/odontoblastic differentiation. Conversely, NFIC knockdown inhibited these processes. These findings highlight NFIC's potential as a therapeutic target for dentin/root regeneration. The study was conducted in vitro and supported by statistical significance with a p-value of <0.05. Further in vivo experiments are needed to confirm these findings. The research received funding from the National Natural Science Foundation of China and other sources.
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