Targeting Olfactory Receptor OR2AT4: An Innovative Aptamer-Based Treatment for Hair Growth Promotion

    June 2025 in “ Molecular Therapy — Nucleic Acids ”
    Manuel Mataix, Nuria Illera, Itzcóatl Alejandro Figueroa Hidalgo … Marta Carretero
    Studysummary In this study, researchers identified a specific DNA aptamer, Ap.OR2AT4.17, that effectively prolonged hair growth and increased hair shaft elongation in organ-cultured human hair follicles by targeting the olfactory receptor OR2AT4. This finding suggests the aptamer's potential as a novel therapy for hair loss disorders.
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    Research cited in this study 8

    1. Activation of Olfactory Receptor 2A4/7 by Cyclohexyl Salicylate Promotes Human Hair Follicle Growth Journal of Investigative Dermatology · 2022
    2. The Potential Relevance of the Microbiome to Hair Physiology and Regeneration: The Emerging Role of Metagenomics Biomedicines · 2021
    3. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    4. Olfactory Receptor OR2AT4 Regulates Human Hair Growth Nature Communications · 2018
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    6. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    7. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    8. Human Hair Growth In Vitro Journal of Cell Science · 1990