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The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

Testosterone therapy can help postmenopausal women with low sexual desire if monitored carefully.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Rats had lasting erectile problems after stopping a certain medication.

Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

Mice with CBS deficiency are healthier on a low-methionine diet.

Scalp flaps are stiffer than skin from other body areas, which helps in planning reconstructive and cosmetic head surgeries.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Polygonum multiflorum can promote hair growth when taken orally or applied topically.

Platelet lysate is more effective than activated autologous platelet-rich plasma or saline in improving hair growth after hair restoration surgery.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Finasteride may improve prostate cancer treatment outcomes.

FAI values above 6.4 may suggest high androgen levels and increased metabolic risks in Chinese women of reproductive age.

Some skin medications can harm male fertility, but they don't seem to cause birth defects from father's exposure.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.

Men with male pattern baldness have a higher risk of dying from prostate cancer.

Scientists found out how a specific protein in human hair cuticles behaves and is structured.

Ketoconazole increases finasteride's effectiveness and lifespan in the body.

Long COVID patients have more health issues than non-infected people.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Aging in men is influenced by genetics and lifestyle, leading to muscle loss, bone issues, and skin damage.

Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.

Different levels of anti-Müllerian hormone can help diagnose polycystic ovary syndrome in women of different ages.