TLDR Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.
The 2013 document provides comprehensive guidelines for the use of acitretin in psoriasis treatment, emphasizing its utility as monotherapy or in combination with other treatments, including phototherapy. Acitretin is particularly effective for severe psoriasis types and has a favorable profile due to its lack of immunosuppressive effects, allowing for long-term use. The guidelines cover dosing, efficacy, adverse effects, and monitoring, noting that side effects are dose-dependent and include mucocutaneous issues, hepatotoxicity, and teratogenicity. Acitretin is contraindicated in pregnancy and requires careful patient selection and monitoring, especially in those with cardiovascular risk factors or metabolic syndrome. It is less effective than other systemic drugs but valuable for its long-term safety profile and lack of immunosuppression, achieving a PASI 75 response in 40% to 50% of patients. The document also acknowledges the authors' financial ties to the pharmaceutical industry related to antipsoriatic drugs.
136 citations
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April 2010 in “British Journal of Dermatology” Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.
75 citations
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August 2005 in “Expert Opinion on Pharmacotherapy” Acitretin is effective for certain types of psoriasis, safe for long-term use, and often combined with other treatments.
1 citations
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January 2021 in “Journal of the Dermatology Nurses’ Association” The convention discussed various skin conditions and treatments, and highlighted the importance of vaccinations for patients on immune-altering medications.
136 citations
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April 2010 in “British Journal of Dermatology” Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.
1 citations
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September 2001 in “PubMed” Acitretin treats severe skin conditions but requires careful monitoring due to serious side effects.
March 2014 in “Journal of The American Academy of Dermatology” The document lists various dermatology topics, treatments, and diagnostic methods.
40 citations
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July 2007 in “Dermatologic Therapy” Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.
4 citations
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June 2002 in “Clinical and experimental dermatology” Effective treatment for hidradenitis suppurativa varies, with antibiotics commonly used and surgery as an option, but no single method is universally successful.
