The Impact of Exogenous Vitamin D on Thyroid Autoimmunity in Euthyroid Men with Autoimmune Thyroiditis and Early-Onset Androgenic Alopecia

June 2021 in “ Pharmacological Reports ”

Robert Krysiak, Karolina Kowalcze, Bogusław Okopień

vitamin D androgenic alopecia autoimmune thyroiditis thyroid autoimmunity SPINA-GT PCOS thyroid antibodies male pattern baldness polycystic ovary syndrome

TLDR Vitamin D may help reduce antibody levels in men with autoimmune thyroiditis and early-onset androgenic alopecia, but has no significant impact on thyroid function.

A study of 67 young men, 25 of whom had early-onset androgenic alopecia, found that exogenous vitamin D supplementation did not have a significant impact on thyroid autoimmunity or thyroid function in euthyroid men with autoimmune thyroiditis and early-onset androgenic alopecia. However, vitamin D may have a positive impact on reducing antibody levels in men with autoimmune thyroiditis and early-onset androgenic alopecia, but the effect is more significant in those without alopecia. Additionally, vitamin D increased SPINA-GT only in those with alopecia. The study suggests that men with early-onset androgenic alopecia and male siblings of women with PCOS have lower levels of vitamin D, and women with PCOS have a higher prevalence of autoimmune thyroiditis and elevated thyroid antibodies.

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Research cited in this study

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research A Cross-Sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men

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research A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women

47 citations, June 2016 in “JAMA Dermatology”

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research Association Between Androgenetic Alopecia and Metabolic Syndrome: A Meta-Analysis

7 citations, September 2014 in “PubMed”

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The Impact of Exogenous Vitamin D on Thyroid Autoimmunity in Euthyroid Men with Autoimmune Thyroiditis and Early-Onset Androgenic Alopecia

research The Impact of Exogenous Vitamin D on Thyroid Autoimmunity in Euthyroid Men with Autoimmune Thyroiditis and Early-Onset Androgenic Alopecia

5 citations, June 2021 in “Pharmacological Reports”

Vitamin D may help reduce antibody levels in men with autoimmune thyroiditis and early-onset androgenic alopecia, but has no significant impact on thyroid function.