October 2025 in “Burns & Trauma” This review highlights recent advancements in engineered probiotics for wound healing, reporting that genetically engineered strains of Lactobacillus reuteri and Lactococcus cremoris have shown promise in promoting faster wound healing in pre-clinical and clinical settings, particularly for diabetic foot ulcers.
124 citations
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November 2000 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that human peptidylarginine deiminase type III is the predominant isoform in hair follicles and may modulate structural proteins during hair and hair follicle formation.
11 citations
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April 2021 in “Cancers” This study identified a small molecule that activates GLI1, suppressing neuroblastoma cell growth, which may aid in developing new treatments for high-risk neuroblastoma cases.
This study found that fibroblasts from Emery-Dreifuss muscular dystrophy patients with certain genetic mutations overexpress markers of fibrosis, and gene correction techniques reduced fibrogenic molecule expression in cell models, suggesting potential therapeutic applications.
This study found that upper-bulge epidermal stem cells in mouse hair follicles are specialized for nerve interactions, crucial for forming tactile sensory units, and influence touch responses via EGFL6 and αv integrin pathways.
In this study, upper-bulge epidermal stem cells in mouse hair follicles were shown to play a role in forming tactile sensory units by creating an extracellular matrix that supports nerve interactions.
8 citations
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July 2022 in “International Journal of Molecular Sciences” This review reports no new results but highlights the secretory function of keratinocytes, focusing on how various secretions, notably growth factors, impact stem cell differentiation into keratinocytes.
1 citations
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May 2022 in “IntechOpen eBooks” This chapter reviews the diverse and interrelated consequences of obesity on physical, metabolic, reproductive, psychosocial, and economic health without reporting any new clinical results.
69 citations
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January 2021 in “Journal of Biological Chemistry” This review discusses various amino acid-derived plant defensive compounds and highlights their potential as drug leads due to their potent antimicrobial properties, but reports no new experimental results.
10 citations
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May 2025 in “Cell Biomaterials” This perspective highlights how advancements in single-cell sequencing and digital pathology can help understand the complex mechanisms of immune responses, fibrosis, and tissue remodeling related to medical implants, aiming to address the challenges of implant-related tissue reactions reported in this study.
1 citations
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January 2022 in “Health” This article discusses the impact of COVID-19 on various sectors and reports no new clinical findings.
In this study, researchers found that Fgf21 knockout mice exhibited delayed hair follicle cycling compared to wild-type mice, potentially due to altered miRNA interactions affecting Vezf1 and Map3k1 expression, providing insights into the molecular regulation of hair growth.
2 citations
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June 2024 in “Frontiers in Immunology” In this study, researchers developed a 3D in-vitro system for generating functional AT-resident macrophages without cell sorting, providing a valuable tool to study their differentiation and function in various physiological and pathological conditions.
44 citations
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November 2022 in “Frontiers in Immunology” This review discusses the role of toll-like receptors in cancer treatment, providing an overview of pre-clinical studies and clinical trials on TLR-targeted therapies and noting the challenges and future prospects.
15 citations
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May 2022 in “Journal of Investigative Dermatology” This study found that endothelial TLR2 is crucial for effective angiogenesis and timely wound healing, whereas TLR2 in hair follicle stem cells is not essential for skin regeneration.
5 citations
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September 2022 in “Journal of Investigative Dermatology” This review discusses factors affecting wound-induced hair neogenesis in mice and reports no new results; it aims to facilitate meaningful comparisons of experiments across different laboratories.
5 citations
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February 2022 in “Stem cell reports” This study found that thymic stromal lymphopoietin (TSLP) promotes hair growth after skin injury by enhancing the proliferation of specific stem cells in hair follicles.
January 2026 in “Immunological Reviews” This review discusses sex differences in immune responses and highlights mechanisms involving sex hormones, X-linked genes, and X-Chromosome Inactivation, but reports no new clinical findings.
This review discusses the mechanisms regulating wound-induced hair-follicle neogenesis and highlights potential treatments, like Wnt signaling activators, for enhancing this process in humans, yet reports no new clinical results.
February 2025 in “International Journal of Molecular Sciences” This meta-analysis of animal studies found that alkaloids have potential anti-influenza and anti-inflammatory effects, correlating with improved viral titers and survival rates, though they did not effectively reduce TNF-α and IL-6 levels. Extensive further studies are needed to confirm these findings before considering clinical application.
51 citations
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January 2024 in “Burns & Trauma” This review summarizes the therapeutic potential and development of engineered extracellular vesicles for tissue repair and regenerative medicine, reporting no new clinical findings.
25 citations
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December 2021 in “Stem Cell Research & Therapy” This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.
24 citations
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November 1997 in “Journal of Biological Chemistry” This study found that genes encoding mouse high-glycine/tyrosine proteins show distinct spatial and temporal expression patterns in hair follicles, suggesting diverse protein distribution during hair growth cycles.
4 citations
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November 2024 in “International Journal of Molecular Sciences” This review explores whether SARS-CoV-2 could trigger or worsen α-synucleinopathies, like Parkinson's disease, by affecting α-synuclein misfolding and aggregation, potentially linking COVID-19 with the development of parkinsonism-like symptoms.
8 citations
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March 2022 in “Frontiers in Cell and Developmental Biology” This study found that intravenous transplantation of human hair follicle-derived mesenchymal stem cells improved trabecular bone mass in osteoporotic mice by enhancing bone formation and reducing bone resorption.
3 citations
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January 2023 in “Science advances” This study found that ablation of Tet2/Tet3 genes in skin epithelial cells altered hair shape and length, leading to hair loss, by affecting chromatin accessibility and gene expression related to hair follicle regulation.
April 2024 in “Journal of translational medicine” This review highlights the diverse roles of melanocytes in pigmentation, immunity, and hearing among other functions, their involvement in disorders, and their emerging potential in regenerative medicine, including applications in disease modeling and therapy development using advanced technologies.
This case report describes a 21-year-old man diagnosed with systemic lupus erythematosus, highlighting the condition's potential to mimic hematological malignancy and the effectiveness of prednisolone in rapid symptom improvement.
421 citations
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January 2015 in “Chemical Society Reviews” This review discusses recent advances in surface modification and endothelialization of biomaterials for vascular grafts, highlighting promising methods like gene engineering and targeting ligand immobilization to improve clinical outcomes.
60 citations
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September 2013 in “Alimentary Pharmacology & Therapeutics” This review discusses the dermatological adverse events from immunosuppressive and anti-TNF therapy in IBD, finding increased risks of non-melanoma skin cancer and other skin conditions, and recommends regular cancer screening.