Fever of Unknown Origin in a Male Patient with Systemic Lupus Erythematosus

January 2017 in “ PubMed ”

Duminda Basnayake, Thamara Kannangara, Laknath Welagedara, Vindhya Bandara, Janitha Herath

systemic lupus erythematosus SLE hair loss oral prednisolone pancytopenia anti-nuclear factor double-stranded DNA hypocomplementemia lupus prednisolone

TLDR SLE should be considered in unexplained fevers, even in males.

A 21-year-old male with systemic lupus erythematosus (SLE) presented with a month-long history of fever, weight loss, loss of appetite, and reduced hair growth. Clinical examination revealed oral ulcers and lymphadenopathy. Laboratory tests showed pancytopenia, positive anti-nuclear and double-stranded DNA antibodies, high erythrocyte sedimentation rate, and hypocomplementemia. The patient was diagnosed with SLE and treated with oral prednisolone, resulting in significant improvement within a week. This case highlighted the importance of considering SLE in male patients with fever of unknown origin, despite its rarity in men.

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