research The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo
Apremilast may help treat hair loss in alopecia areata.
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90-120 / 295 resultsresearch Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients
EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.
research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition
Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
research Expansion of Bacterial Phosphatidylglycerol Reactive CD4+ T Cells in Atopic Dermatitis
People with atopic dermatitis have more CD4+ T cells that respond to a certain bacterial lipid, which may play a role in the skin condition's inflammation.
research Replicative Stress, Stem Cells, and Aging
Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.
research Orchestrated Cytotoxic and Skin Migratory Ability Lacking Self-Tolerance: Circulating γδT-Cells May Promote Alopecia Areata
The role of γδT-cells in causing alopecia areata remains unclear.
research Effect of Topical Gel Administration of Secretome Hypoxia Mesenchymal Stem Cells on IL-10 and TNF-α Gene Expression: An In Vivo Experimental Study in Male Wistar Rats with Fluconazole-Induced Alopecia
SH-MSCs gel can effectively treat alopecia by increasing IL-10 and decreasing TNF-α gene expression.
research Pro-Inflammatory Vδ1+ T-Cells Infiltrates Are Present In And Around The Hair Bulbs Of Non-Lesional And Lesional Alopecia Areata Hair Follicles
Targeting Vδ1+T-cells may help treat alopecia areata.
research The Immune Functions of Keratinocytes in Skin Wound Healing
Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
research Immune Modulation of Hair Follicle Regeneration
Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.
research Resident Human Dermal Gamma Delta T-Cells Operate as Stress Sentinels: Lessons from the Hair Follicle
Human dermal γδT-cells respond to stress in hair follicles, contributing to hair loss.
research Immune Cell Regulation of the Hair Cycle
Immune cells affect hair growth and could lead to new hair loss treatments.
research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles
Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.
research MAIT Cells in COVID-19: Heroes, Villains, or Both?
MAIT cells may help fight COVID-19 but also contribute to severe inflammation.
research Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice
Increasing Treg cells in the skin does not cure hair loss from alopecia areata in mice.
research Possible Role of ILC1 in the Pathogenesis of Alopecia Areata
ILC1 cells contribute to hair loss in alopecia areata.
research Mesenchymal Stem Cells for the Treatment of Skin Diseases
Mesenchymal stem cells show promise for treating various skin conditions and may help regenerate hair.
research Scarring Hair Follicle Destruction Is Driven by the Collapse of EGFR-Protected JAK-STAT1-Sensitive Stem Cell Immune Privilege
A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.
research Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT
Mint water extract boosts protective enzymes in skin cells.
research Resident Memory T Cells in Autoimmune Skin Diseases
Certain immune cells contribute to skin autoimmune diseases, and some treatments can reverse hair loss in these conditions.
research Regulatory T Cells in Skin Regeneration and Wound Healing
Regulatory T cells help heal skin and grow hair, and their absence can lead to healing issues and hair loss.
research Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle
Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.
research TGFβ and Cancer Metastasis: An Inflammation Link
TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
research Endocannabinoid-Like Molecule Oleoylethanolamide Promotes Sebaceous Lipid Synthesis
Oleoylethanolamide (OEA) safely boosts fat production in skin cells and may help treat dry skin and reduce inflammation.
research Nicotinic Acid Suppresses Sebaceous Lipid Synthesis of Human Sebocytes via Activating Hydroxycarboxylic Acid Receptor 2 (HCA2)
Nicotinic acid reduces excessive oil production in skin cells by activating a specific receptor, which could help treat acne.
research Getting to the Root of Hair Loss in Alopecia
Specific immune cells cause alopecia areata and blocking certain proteins can prevent it.
research Fractional Laser-Assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review
Fractional lasers and microneedling, combined with topical agents, could potentially treat Alopecia Areata effectively, but more research is needed due to limited data.
research Alopecia Areata: Medical Treatments
Some treatments for autoimmune hair loss work, but JAK inhibitors like tofacitinib are promising for regrowth.
research Environmental Pathobiology of Frontal Fibrosing Alopecia: Does Linalool Promote FFA Development and Progression by Inducing Epithelial Hair Follicle Stem Cell Damage and MICA Expression in the Bulge?
Linalool in personal care products may worsen frontal fibrosing alopecia by damaging hair follicle stem cells and triggering harmful immune responses.
research Mechanisms Regulating Skin Immunity and Inflammation
The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.