Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT

    May 2018 in “ Journal of Investigative Dermatology ”
    Hye Kyoung Han, Miji Yeom, Seoungwoo Shin, D. Park, Eun-chung Jung
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    TLDR Mint water extract boosts protective enzymes in skin cells.
    The document from 2018 detailed a study on the effects of Mentha suaveolens aqueous extract (MSAE) on human keratinocyte HaCaT cells, demonstrating that MSAE increases Nrf-2 activity in a dose-dependent manner without cytotoxic effects. MSAE also upregulated the expression of phase II detoxifying enzymes like heme oxygenase-1 (HO-1) and glutamyl cysteine ligase (GCLC), and provided protection against hydrogen peroxide-induced cell damage. These findings indicate that MSAE may offer keratinocytes protection from oxidative stress by boosting Nrf-2 mediated enzyme expression. The study did not specify the number of cells or participants involved.
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