Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT

April 2018 in “ Journal of Investigative Dermatology ”

Hye Kyoung Han, Miji Yeom, Seoungwoo Shin, D. Park, Eun-chung Jung

Mentha suaveolens aqueous extract Nrf-2 human keratinocyte HaCaT cells heme oxygenase-1 HO-1 glutamyl cysteine ligase GCLC oxidative stress hydrogen peroxide mint extract skin cells antioxidant enzymes detoxifying enzymes H2O2

TLDR Mint water extract boosts protective enzymes in skin cells.

The document from 2018 detailed a study on the effects of Mentha suaveolens aqueous extract (MSAE) on human keratinocyte HaCaT cells, demonstrating that MSAE increases Nrf-2 activity in a dose-dependent manner without cytotoxic effects. MSAE also upregulated the expression of phase II detoxifying enzymes like heme oxygenase-1 (HO-1) and glutamyl cysteine ligase (GCLC), and provided protection against hydrogen peroxide-induced cell damage. These findings indicate that MSAE may offer keratinocytes protection from oxidative stress by boosting Nrf-2 mediated enzyme expression. The study did not specify the number of cells or participants involved.

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Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT

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