Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT
April 2018
in “
Journal of Investigative Dermatology
”
Studysummary This study found that Mentha suaveolens aqueous extract activated Nrf-2 and increased detoxifying enzyme expression in keratinocytes, providing protection against oxidative stress without cytotoxicity.
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The document from 2018 detailed a study on the effects of Mentha suaveolens aqueous extract (MSAE) on human keratinocyte HaCaT cells, demonstrating that MSAE increases Nrf-2 activity in a dose-dependent manner without cytotoxic effects. MSAE also upregulated the expression of phase II detoxifying enzymes like heme oxygenase-1 (HO-1) and glutamyl cysteine ligase (GCLC), and provided protection against hydrogen peroxide-induced cell damage. These findings indicate that MSAE may offer keratinocytes protection from oxidative stress by boosting Nrf-2 mediated enzyme expression. The study did not specify the number of cells or participants involved.
