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This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.

This review explores the potential of selective 11β-HSD1 inhibitors to improve insulin sensitivity in type 2 diabetes, emphasizing the need for more clinical research and reports no new clinical results.

This study demonstrated that a multifunctional hydrogel containing Prussian blue nanozymes and an ultrasound-responsive nitric oxide donor improved healing in diabetic wounds by reducing oxidative stress, promoting angiogenesis, and enhancing tissue repair in animal models.

Amlodipine cream may help hair growth by improving blood flow.

Minoxidil affects rat fluid dynamics, altering pressure and circulation, improving blood flow and hair growth.

This review discusses the development and selectivity of 5 alpha-reductase inhibitors, particularly non-steroidal ones, and reports no new clinical trial results.

This Cochrane review reports that 5-alpha reductase inhibitors may slightly reduce urological symptoms and acute urinary retention risk compared to placebo, with a possible small reduction in surgical intervention need compared to alpha blockers.

This study found that minoxidil is highly effective in managing severe hypertension in hemodialysis patients without affecting renal function, though it may cause hair growth.

In isolated rat lymph vessels, this study found that ATP-sensitive potassium channel openers impair lymph contractions and reduce lymph flow, potentially contributing to peripheral edema.

This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.

This study identified ten novel compounds that may effectively target steroid 5 alpha-reductase 2 (5αR-2) for potential treatment of benign prostate hyperplasia, exhibiting comparable binding energies to existing drugs like finasteride and dutasteride.

This report describes a case of prolonged distributive shock attributed to minoxidil overdose, which involved intentional ingestion alongside trauma and NSAIDs, successfully managed with medications and hydration despite persistent low blood pressure.

Minoxidil treatment in mice preserved the integrity of elastic lamellae and improved arterial biomechanical properties, especially in females, suggesting it could be an anti-arterial aging agent potentially suitable for female-targeted therapies.

This study found that finasteride effectively reduced cardiac hypertrophy and improved heart function in male mice, suggesting a potential role of DHT in cardiac remodeling and highlighting 5-α-reductase inhibition as a possible therapy.

This study found that dutasteride more effectively reduced serum dihydrotestosterone levels than finasteride in patients with benign prostatic hyperplasia.

This article reviews the mechanism, usage, and alternatives of the medication minoxidil in dermatology and reports no new clinical outcomes.

This review discusses the management options for recurrent ischemic priapism, noting that ketoconazole, finasteride, and other hormonal therapies may be effective but can have significant side effects; it reports no new clinical findings.

This review discusses the role of 5α-reductase in prostate development and BPH, and reports no new clinical results; ongoing trials are exploring dual isozyme inhibitors for improved treatment efficacy.

This study found that while new treatments like Optilume, Rezum, and Aquablation have minimal risks of sexual dysfunction, they offer less improvement in lower urinary tract symptoms compared to traditional surgeries like TURP, though Aquablation does reduce ejaculatory dysfunction more effectively than TURP.

Finasteride and dutasteride have little effect on Type 2 Diabetes risk.

In this study, minoxidil was found to have low toxicity in various animals, with specific heart lesions observed only in dogs at certain doses.

This study found that torilin from Torilis japonica fruit extract inhibited 5 alpha-reductase in vitro more effectively than alpha-linolenic acid but less effectively than finasteride.

This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.

This study found that a novel thiohydantoin derivative, 3a, effectively inhibited androgen receptor activity in LNCaP cells and showed promising in vivo results by reducing testosterone-induced prostate changes, outperforming finasteride in mitigating prostate index and histopathological alterations.

This study aims to compare the differences in adverse reactions and efficacy between topical and oral use of minoxidil for hair growth, with a focus on newer, lower-dose oral applications originally used for hypertension.

This study found that novel compounds moderately inhibited 5α-reductase type 1 activity compared to finasteride, offering valuable data on structure-activity relationships.

This review discusses the sexual side effects of medical and surgical treatments for benign prostatic hyperplasia, such as erectile dysfunction and changes in ejaculation, but presents no new clinical findings.

DMG-Na may help reduce hair loss and improve hair growth, but more research is needed.

This study found that minoxidil significantly reduced supine diastolic pressure in 94% of patients with severe essential hypertension within 4 weeks, but some patients experienced side effects such as increased hair growth and fatigue.

This study demonstrated that benzothiazepines, such as diltiazem and JTV-519, exert anxiolytic-like effects through allopregnanolone biosynthesis in mice, similar to carbamazepine.