Ultrasound-Responsive Hydrogel with ROS Scavenging and NO Controllable Release Capabilities for Accelerated Healing of Diabetic Wounds

    January 2026 in “ Materials Today Bio ”
    Jun Luo, X. Q. Yan, Kang Fu, Yuxuan Qiu, Yana Xu, Zhaojie Wang, Xuexiao Li, Ting Lin, Y Wang, Yunting Zhang, Yawei Yu, Jia Wen, Jianqing Gao, Gaoyi Yang
    TLDR The hydrogel speeds up diabetic wound healing by reducing inflammation and promoting skin repair.
    The study introduces an ultrasound-responsive hydrogel (PBE&SNO@HG) designed to enhance diabetic wound healing by scavenging reactive oxygen species (ROS) and releasing nitric oxide (NO) on demand. The hydrogel, which combines Prussian blue nanozymes for ROS scavenging and an ultrasound-triggered NO donor, promotes angiogenesis, reduces inflammation, and supports wound remodeling. In vitro and in vivo tests, including a small animal cohort (n=3), demonstrated the hydrogel's ability to improve wound closure rates, enhance skin regeneration, and increase collagen deposition and neovascularization in diabetic rats. The hydrogel showed good biocompatibility, hemocompatibility, and potential for chronic wound management, with future research focusing on larger sample sizes and clinical applicability.
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