Severe and Refractory Hypotension After Intentional Minoxidil Overdose: A Case Report

    December 2023 in “ Toxicology communications ”
    Mir Nadeem Mazhar, Adrián Estrada, Alexander Zorn, Robert Madlinger, M Miglietta
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    TLDR Minoxidil overdose caused severe low blood pressure, but the patient recovered with specific treatments.
    This case report describes an 18-year-old male who experienced severe and prolonged hypotension after intentionally ingesting a topical minoxidil-finasteride spray, along with NSAIDs and a detergent pod. Despite initial trauma and minimal bleeding, the patient's hypotension was attributed to the minoxidil overdose. He was managed with phenylephrine, vasopressin, midodrine, and IV fluids, and required intensive hemodynamic monitoring. The patient developed acute heart failure and pulmonary edema but eventually recovered and was discharged after 12 days. This case highlights the severe and prolonged effects of minoxidil overdose and the importance of appropriate vasopressor support and fluid resuscitation.
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