Prolonged Hypotension Induced by Ingesting a Topical Minoxidil Solution: Analysis of Minoxidil and Its Metabolites

    March 2016 in “ Acute medicine & surgery ”
    Shinichi Kikuchi, Yuji Fujita, Makoto Onodera, Yasuhisa Fujino, Yoshihiro Inoue
    Image of study
    TLDR Swallowing a lot of minoxidil, a hair growth liquid, can cause severe and long-lasting low blood pressure.
    In 2016, a 47-year-old man suffered prolonged hypotension after ingesting 60 mL of a topical minoxidil solution, equivalent to 3,000 mg of minoxidil. His serum concentration of minoxidil sharply decreased from 4,994 ng/mL to 33.9 ng/mL within 12 hours, yet he still required vasopressor support for four days. Urine analysis 16 hours after ingestion revealed higher levels of minoxidil-O-glucuronide (1,953 ng/mL) than unchanged minoxidil (360.4 ng/mL) or minoxidil-N-O-sulfate (104.5 ng/mL). The case demonstrated that ingestion of large amounts of topical minoxidil can lead to severe and lasting cardiovascular effects, and monitoring minoxidil-O-glucuronide in urine is an effective method for diagnosing minoxidil poisoning.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 1 year ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

      community Insane dutasteride shed 4 months after switching.

      in Finasteride/Dutasteride  115 upvotes 1 year ago
      The post and conversation are about a user's experience with hair loss treatments, specifically switching from finasteride to dutasteride. The user experienced significant hair shedding after the switch, with others suggesting patience, noting similar experiences, or questioning the user's decision and medical consultation.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 month ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

    Similar Research

    5 / 1000+ results