Katp Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema

The study found that ATP-sensitive potassium (KATP) channel openers (KCOs) such as cromakalim and minoxidil sulfate inhibited lymphatic contractions and reduced lymph flow in isolated rat mesenteric lymph vessels, potentially contributing to peripheral edema. KCOs impaired lymphatic function by hyperpolarizing lymphatic muscle cells, which inhibited contractions and decreased lymph flow by up to 38.4%. The research identified KATP channel subunits in lymphatic muscle cells as Kir6.1/6.2 and sulfonylurea receptor 2, differing from those in arterial muscle, suggesting that KCOs might target these channels differently. This highlighted the potential for developing KCOs that selectively target arterial channels to avoid adverse effects on lymphatic function, emphasizing the need for further research to confirm these findings in humans.