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390-420 / 1000+ resultsresearch Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer
This study suggests that the NCSTN knockout mouse could serve as an HS animal model, with tamoxifen potentially used for gene deletion in mice.
research Targeting noncanonical nuclear factor kappa B signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha
In this study, researchers found that inhibiting IKKα in patient-derived CCS tumour models reduces tumour viability, supporting the potential for topical IKKα inhibitors as a treatment for CCS.
research Letter
Infrared light might help treat stubborn alopecia areata.
research An evaluation of the RapidHIT™ ID system for hair roots stained with Diamond™ Nucleic Acid Dye
This study found that the RapidHIT™ ID system can successfully obtain DNA profiles from single hair roots, particularly those with high nuclei counts.
research Triggered release of model drug from AuNP-doped BSA nanocarriers in hair follicles using IRA radiation
This study found that water-filtered infrared A radiation can induce the release of a model drug from gold nanoparticle-doped particles in hair follicles in an ex vivo porcine skin model, suggesting feasibility for follicular drug delivery systems.
research Congress abstracts SPEDM
In this study, researchers found that both the EU-TIRADS and Bethesda systems exhibited high specificity but suboptimal sensitivity for predicting thyroid nodule malignancy in patients who underwent surgery, with Bethesda system showing particularly high specificity in this postoperative population.
research The Synthesis of 2,2-BIS(1-INDOL-3-YL)Acenaphthylene-1(2)-Ones Using Nanocatalysis: Fluorescent Sensing for Cu2+ Ions
This study synthesized indole-acenaphthylene compounds using a magnetic nanocatalyst and explored their photoluminescence properties for detecting copper ions in a mixed solvent system, achieving a detection limit of 9.5 ∙ 10 –6 M.
research 575 INTASYL self-delivering RNAi: A flexible platform to treat dermatological malignancies
INTASYL is a promising, adaptable RNAi technology for treating skin cancers.
research peri ‐Xanthenoxanthene (PXX): a Versatile Organic Photocatalyst in Organic Synthesis
This study reports that the dye peri-xanthenoxanthene (PXX) can act as an efficient photocatalyst for various radical reactions, including complex dual catalytic processes and the synthesis of an investigational drug intermediate.
research 1112 An innovative phase 1b trial demonstrating proof-of-pharmacology for two novel IRAK4-inhibitors using a local (Imiquimod) and systemic (LPS) driven immune response
This study found that the oral IRAK4-inhibitors BAY 1834845 and BAY 1830839 reduced skin inflammation and systemic inflammatory responses in healthy volunteers, showing similar pharmacodynamic effects to prednisolone when challenged with topical imiquimod and intravenous LPS.
research Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker gene ID2, by contact sensitizers in human bulge‐derived keratinocytes
This study found that the ID2 gene was highly expressed in bulge-derived keratinocytes when exposed to contact sensitizers and may serve as a marker to distinguish sensitizers from irritants during in vitro testing.
research 267 Single- and multiple-ascending dose studies of DS-2325a, a KLK5 inhibitor for the treatment of Netherton syndrome
In these two clinical trials, DS-2325a, a KLK5 inhibitor, was found to be generally safe and well tolerated in healthy volunteers, with mild and non-serious adverse events, suggesting its potential for further development as a treatment for Netherton Syndrome.
research Accumulation of I131 by the skin and hair of animals and man
Radioiodine-131 significantly accumulates in skin and hair.
research Test activity of hair tonic of ethyl acetate fraction from the ethanol extract of meniran (Phyllanthus niruri L.) as hair grower to male white rat (Rattus norvegicus) wistar strain
This study found no significant differences in hair growth between two formulas of hair tonic from meniran extract, one with a menthol enhancer, despite variations in hair length and weight measurements.
research Combination Therapy with Baricitinib and Narrowband Ultraviolet B for Active Non-Segmental Vitiligo: A Retrospective Controlled Study
This study suggests that combining baricitinib with narrowband UV-B therapy is an effective and well-tolerated approach for treating active nonsegmental vitiligo.
research LB1159 First-in-human clinical trial evaluating AI-09, a novel long-lasting ready-to-use liquid injectable neuromodulator for the treatment of glabellar lines
AI-09 is safe, effective, and reduces wrinkles for up to 6 months.
research 0497 Periderm without IRF6: To be or not to be
research 75202 Evaluation of the anti-dandruff and soothing effect of a hair conditioner containing 0.4% piroctone olamine and niacinamide
research XEDAR activates the non-canonical NF-κB pathway
This study found that the XEDAR receptor can activate the non-canonical NF-kB pathway involving p100 processing, which is regulated by interactions with TRAF proteins and specific kinases.
research Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice
In this study, the deletion of NIPP1 in keratinocytes led to chronic skin inflammation and epidermal changes in mice, with early cell-cycle arrest and premature senescence observed, potentially contributing to reduced mutagen sensitivity.
research The Influence of Menthol in Ethanol Extract of Meniran Gel (Phyllanthus niruri L.) as a Hair Growth Promoter in Male Wistar Rats
This study found that adding menthol to Phyllanthus niruri ethanol extract gel enhanced hair growth and thickness in rats.
research IPL sources and ruby lasers for hair reduction - trying to compare apples and oranges
Choose IPL for versatility and speed, ruby lasers for precision.
research Detection of Iodine by Scanning Electron Microscopy(SEM) and Energy Dispersive Spectroscopy(EDS) Following Contact with an Iodine Releasing Coating
This study used novel methods to detect and map iodine concentrations in pig skin, finding iodine present in the coating, stratum corneum, and tissue around hair follicles.
research 576 INTASYL PH-762: Intratumoral immunotherapy targeting PD-1
PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.
research On the Use of Micro-Imager® to Directly Visualize Drug Distribution in Human Skin
This article discusses a new device for visualizing and quantifying skin distribution of a radioactively labelled compound, but reports no new clinical results.
research 877 Loss of UBE2N in keratinocytes leads to skin inflammation and immune infiltration through IRAK1/4-mediated processes
This study found that deleting Ube2n in adult mouse skin leads to inflammation and other skin changes, and identifies IRAK1/4 as potential treatment targets for inflammatory skin disorders.
research Evaluation of permissible level of soluble I-131 containing fission products for design of protective measures in livestock industry
In this study, heifers exposed to thyroid irradiation up to 30 Gy showed changes in thyroid hormone levels but tended toward recovery, without affecting immunity or productivity.
research Formulation of Hair Tonic of Meniran (Phyllanthus niruri L.) Ethanol Extract as Hair Grower in Male White Rat (Rattus norvegicus) Wistar Strain
In this study, topical application of tonic preparations containing 5% ethanol extract of Phyllanthus niruri to shaved mice showed potential as a hair growth enhancer, as indicated by observations of increased hair length and weight over a 21-day period.
research PNU 157706, a novel dual type I and II5α-reductase inhibitor
This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.