Expression of Nicastrin, NICD1, and Hes1 in NCSTN Knockout Mice: Implications for Hidradenitis Suppurativa, Alzheimer’s, and Liver Cancer

    December 2024 in “ European journal of medical research ”
    Yan Lu, Yinsen Song, Jian Zhou … Jianguo Li
    Studysummary This study suggests that the NCSTN knockout mouse could serve as an HS animal model, with tamoxifen potentially used for gene deletion in mice.
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    Research cited in this study 2

    1. Hidradenitis Suppurativa Secondary to Treatment With a Gamma Secretase Inhibitor JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2023
    2. Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling Stem Cells · 2019