Does Nicastrin Deficiency Cause Melanocytotoxicity in Human Skin as in the Fish Counterpart?

    May 2021 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Cheng‐Hsing Hsu, Yun-Jin Jiang
    Studysummary This research discusses a zebrafish model showing that nicastrin deficiency leads to tyrosinase-dependent depigmentation and melanophore cell death, suggesting implications for studying skin depigmentation disorders.
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    Research cited in this study 7

    1. Inhibition of Glycosphingolipid Synthesis Reverses Skin Inflammation and Hair Loss in ApoE−/− Mice Fed Western Diet Scientific Reports · 2018
    2. Mutations in Gamma-Secretase Subunit-Encoding PSENEN Underlie Dowling-Degos Disease Associated with Acne Inversa Journal of Clinical Investigation · 2017
    3. Pharmacological BACE1 and BACE2 Inhibition Induces Hair Depigmentation by Inhibiting PMEL17 Processing in Mice Scientific reports · 2016
    4. Keratinocytes Regulate the Function of Melanocytes Dermatologica sinica/Zhōnghuá pífūkē yīxué zázhì · 2014
    5. Cell Death by Cornification Biochimica et biophysica acta. Molecular cell research · 2013
    6. Mutations in ABCB6 Cause Dyschromatosis Universalis Hereditaria Journal of Investigative Dermatology · 2013
    7. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011