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This review analyzed 12 clinical studies on extracellular vesicle therapies, finding potential benefits for skin aging, acne scars, alopecia, and wound healing, but highlighted significant challenges like production standardization and lack of large-scale studies.

This study found that patients with alopecia areata exhibited increased CRHR1 expression on circulating monocytes compared to controls, suggesting that stress-related factors like CRH and CRHR1 may contribute to the development and progression of the condition, particularly in chronic cases and those with larger lesions.

This study highlights how the COVID-19 pandemic has exacerbated stress-related dermatological issues like acne and hair loss by affecting skin and hair cycles through stress hormones, emphasizing the need for comprehensive psychoneuroendocrine-informed approaches to diagnosis and treatment.

This review summarizes recent findings on how the dysregulated PI3K/Akt/mTOR pathway contributes to immune-mediated inflammatory skin disorders and discusses the potential of natural products, synthetic compounds, and biologic agents in their treatment. However, it emphasizes the need for further research to develop effective therapies.

This review suggests systemic changes in polycystic ovary syndrome may increase the risk of neurodegeneration, potentially linking it to Alzheimer's disease through common pathways affecting tryptophan metabolism.

This review discusses the role of corticotropin-releasing hormone in human skin, focusing on its regulation, receptors, and functions, and highlights parallels with the hypothalamo-pituitary-adrenal axis; it reports no new research findings.

This review outlines key considerations for designing fluorescence microscopy experiments in cell biology, discussing the importance of hardware availability, suitability of biological models, and imaging agents to achieve high-resolution and informative images.

This review discusses how various nutrients, such as flavonoids, probiotics, and omega-3 fatty acids, may support brain health by targeting stress-related pathways, potentially offering protective effects against neurodegenerative and psychiatric disorders through their roles in oxidative stress reduction and neuroinflammation regulation.

This review summarizes evidence suggesting that excess androgens play a key role in the origins of polycystic ovary syndrome, highlighting opportunities for developing targeted treatments.

This review discusses the role of gut steroids in communicating with the gut microbiota and their potential implications in treating gastrointestinal disorders and related brain conditions, suggesting new perspectives on steroid molecules as therapeutic agents.

This study found that progesterone and its metabolite, allopregnanolone, provided anti-anxiety and anti-depressive effects in female mice, potentially independent of nuclear progestin receptors but requiring 5α-reduction and estradiol's influence on brain-derived neurotrophic factor.

This review examines recent advances in bioelectronic nanogenerators for anti-cancer therapy, highlighting various transducing strategies such as photodynamic therapy and electrical stimulation, while also discussing the potential mechanisms for tissue repair and the challenges that lie ahead.

This study found that women with PCOS had higher levels of serum phoenixin isoforms, which correlated with reproductive and metabolic markers, suggesting these isoforms may have a potential diagnostic role.

This meta-analysis found a significantly higher prevalence of depressive symptoms in women with PCOS compared to a control group, with 42.11% versus 13.62% according to the BDI assessment, highlighting the need for psychiatric evaluation and support for women with this syndrome.

This study detected insomnia risk signals associated with various medications, primarily nervous system drugs, using the FDA's Adverse Event Reporting System data from 2004 to 2024.

In this narrative hypothesis-driven overview, the authors propose reframing rosacea as a neuroimmune disorder, highlighting the interconnected role of the skin-gut-brain axis, particularly central nervous system involvement alongside gut microbiota and neurogenic inflammation, to emphasize the need for multidisciplinary therapeutic approaches.

In this study, researchers observed that chronic stress affected wild-derived house mice differently by sex, with females showing less weight gain and distinct behavioral changes, while males exhibited higher hair corticosterone levels, suggesting divergent coping strategies and implications for sex-specific stress assessment protocols.

This review discusses the off-label use of SSRIs to manage inappropriate sexual behavior in elderly dementia patients and highlights the unclear risk of post-SSRI sexual dysfunction, noting a need for high-quality clinical trials.

In this review, researchers explored hair as a promising tool for identifying biomarkers in schizophrenia, highlighting its potential for supporting personalized medicine through ease of sampling, though acknowledging challenges like individual variability and methodological inconsistencies.

This study analyzed reports from the FDA Adverse Event Reporting System and observed an upward trend in suicidality-related safety signals among young male finasteride users since 2019, peaking in 2022, highlighting emerging psychiatric safety concerns and the need for vigilant monitoring of this population.

In this literature review, it was reported that mental health disorders may both contribute to and be exacerbated by various types of hair loss, and an interdisciplinary treatment model is recommended for effective diagnosis and patient care.

This review examines sulforaphane's interactions with hormone-mediated health conditions, focusing on gender-specific health issues, but reports no new original research findings.

This study reviews current evidence on the role of ILC3s in the skin, highlighting their potential involvement in responding to microbiome changes such as those associated with acne and suggesting gaps in understanding their mechanisms.

This study suggests that post-finasteride syndrome and post-SSRI sexual dysfunction share potential etiopathogenetic mechanisms involving brain modulators, neurotransmitters, and gut microbiota, although more research is needed to understand these conditions fully.

This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.

This review discusses the mechanism of action of melatonin in various disorders and suggests its potential for designing new receptor ligands, but reports no new clinical findings.

This study found that 3alpha-diol, an androgen metabolite, improved cognitive and affective performance in aged male rats, suggesting its role in countering age-related decline in hippocampally-influenced behaviors.

This article reviews recent advancements in understanding the diverse populations of skin stem cells and their role in skin homeostasis, but it reports no new experimental findings.

This review summarizes research on androgens' roles in female reproductive function, noting their impact on IVF outcomes and the development of PCOS, and highlights the need for mechanism-based therapies.

This review highlights the potential of in vivo reprogramming using OSKM transcription factors for developing rejuvenating and regenerative strategies, while noting the associated risk of tumorigenicity and discussing how improved understanding could lead to safer applications.