The Potential of Hair Matrix for Biomarker Analysis in Schizophrenia

    September 2025 in “ International Journal of Molecular Sciences ”
    Enric Rubio-Contreras, Nora Guasch-Capella, Albert Martínez-Pinteño … Constanza Morén
    Studysummary In this review, researchers explored hair as a promising tool for identifying biomarkers in schizophrenia, highlighting its potential for supporting personalized medicine through ease of sampling, though acknowledging challenges like individual variability and methodological inconsistencies.
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    Research cited in this study 8

    1. Associations of Schizophrenia with the Activities of the HPA and HPG Axes and Their Interactions Characterized by Hair-Based Biomarkers Psychoneuroendocrinology · 2024
    2. The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    3. Hair Cortisol Concentrations in Mental Disorders: A Systematic Review Physiology & behavior · 2020
    4. Cheating on Forensic Hair Testing? Detection of Potential Biomarkers for Cosmetically Altered Hair Samples Using Untargeted Hair Metabolomics Analyst · 2020
    5. Dietary Glucoraphanin Prevents the Onset of Psychosis in Adult Offspring After Maternal Immune Activation Scientific reports · 2018
    6. Hair Cortisol in Drug-Naïve First-Episode Individuals with Psychosis Brazilian Journal of Psychiatry · 2016
    7. Abnormal Neuronal Differentiation and Mitochondrial Dysfunction in Hair Follicle-Derived Induced Pluripotent Stem Cells of Schizophrenia Patients Molecular psychiatry · 2013
    8. Dose–Hair Concentration Relationship and Pigmentation Effects in Patients on Low-Dose Clozapine Forensic Science Medicine and Pathology · 2007