Hair Cortisol Concentrations in Mental Disorders: A Systematic Review

    November 2020 in “ Physiology & behavior
    Elli Koumantarou Malisiova, Iraklis Mourikis, Christina Darviri, Nicolas C. Nicolaides, Iannis M. Zervas, Charalabos Papageorgiou, George P. Chrousos
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    Studysummary This review found that patients with depression generally have higher hair cortisol concentrations compared to healthy controls, while those with PTSD tend to have lower concentrations.
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    This systematic review examined hair cortisol concentrations (HCC) to assess basal HPA axis activity in various mental disorders. The review included cross-sectional studies comparing psychiatric patients and healthy controls. Despite the growing interest in using HCC for long-term cortisol measurement, results were inconsistent across studies. The review highlighted the need for further cross-sectional and longitudinal studies to better understand HPA axis activity and its association with mental disorders and relapse risk. The authors recommended standardizing HCC measurement protocols for future research.
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