Are Women with Polycystic Ovary Syndrome at Increased Risk of Alzheimer's Disease? Lessons from Insulin Resistance, Tryptophan and Gonadotropin Disturbances and Their Link with Amyloid-Beta Aggregation

This review investigates the potential link between polycystic ovary syndrome (PCOS) and an increased risk of Alzheimer's disease (AD), focusing on shared mechanisms like insulin resistance, tryptophan metabolism disturbances, and gonadotropin imbalances. These factors may contribute to neurodegeneration by promoting amyloid-beta aggregation, a hallmark of AD. The study highlights that metabolic and hormonal imbalances in PCOS could exacerbate pathways leading to neurodegenerative changes, emphasizing the kynurenine pathway's role in both conditions. Despite the lack of direct evidence, the review underscores the need for further research to understand these complex interactions and their implications for long-term neurological health.