Are Women with Polycystic Ovary Syndrome at Increased Risk of Alzheimer's Disease? Lessons from Insulin Resistance, Tryptophan and Gonadotropin Disturbances and Their Link with Amyloid-Beta Aggregation

    July 2024 in “ Biomolecules ”
    Joachim Sobczuk, Katarzyna Paczkowska, Szymon Andrusiów … Jacek Daroszewski
    Studysummary This review suggests systemic changes in polycystic ovary syndrome may increase the risk of neurodegeneration, potentially linking it to Alzheimer's disease through common pathways affecting tryptophan metabolism.
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    Research cited in this study 9

    1. Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome European journal of endocrinology · 2023
    2. Neuroendocrine Determinants of Polycystic Ovary Syndrome International Journal of Environmental Research and Public Health · 2022
    3. PCOS and Depression: Common Links and Potential Targets Reproductive Sciences · 2021
    4. Depression and Anxiety in Women with Polycystic Ovarian Syndrome: A Literature Survey International journal of adolescent medicine and health · 2021
    5. Male Equivalent Polycystic Ovarian Syndrome: Hormonal, Metabolic, and Clinical Aspects DOAJ (DOAJ: Directory of Open Access Journals) · 2020
    6. Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance, and Obesity Clinica Chimica Acta · 2019
    7. Position Statement of the Polish Society of Endocrinology, Polish Society of Gynaecologists and Obstetricians, and Polish Society of Gynaecological Endocrinology on the Diagnosis and Treatment of Polycystic Ovary Syndrome Endokrynologia Polska · 2018
    8. Does a Male Polycystic Ovarian Syndrome Equivalent Exist? Journal of Endocrinological Investigation · 2017
    9. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016