The Frequency of Polycystic Ovary Syndrome in Women With Prediabetes Compared With Normoglycemic Women

    November 2025 in “ Frontiers in Endocrinology ”
    Cem Sulu, Ipek Pervaz, Turgut Gürer, Doğan Yıldız, A.C. Tas, Ahmet Numan Demir, Serdar Şahin, Hande Mefkure Özkaya, Dildar Konukoğlu, Abdullah Tüten, Taner Damcı, Fahrettin Kelestimur, Mustafa Sait Gönen
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    Studysummary This study indicated that prediabetes may make ovaries more susceptible to PCOS-like changes, with mild hyperglycemia potentially having harmful effects on ovarian health. Our plain-language summary of this paper — not a Tressless recommendation.
    The study found that while the overall rate of polycystic ovary syndrome (PCOS) was not higher in women with prediabetes compared to normoglycemic women, there was a notable trend of increased risk in the impaired glucose tolerance (IGT) subgroup. In the prediabetes group, a positive correlation was observed between insulin levels and testosterone, antral follicle count, and ovarian volume, suggesting that prediabetes may make ovaries more susceptible to PCOS-like changes. Additionally, lower anti-Müllerian hormone (AMH) levels in the prediabetes group indicated potential toxic effects of even mild hyperglycemia on the ovaries.
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