The Frequency of Polycystic Ovary Syndrome in Women With Prediabetes Compared With Normoglycemic Women

    November 2025 in “ Frontiers in Endocrinology ”
    Cem Sulu, Ipek Pervaz, Turgut Gürer, Doğan Yıldız, A.C. Tas, Ahmet Numan Demir, Serdar Şahin, Hande Mefkure Özkaya, Dildar Konukoğlu, Abdullah Tüten, Taner Damcı, Fahrettin Kelestimur, Mustafa Sait Gönen
    TLDR Women with prediabetes may have a higher risk of PCOS-like changes, especially if they have impaired glucose tolerance.
    The study found that while the overall rate of polycystic ovary syndrome (PCOS) was not higher in women with prediabetes compared to normoglycemic women, there was a notable trend of increased risk in the impaired glucose tolerance (IGT) subgroup. In the prediabetes group, a positive correlation was observed between insulin levels and testosterone, antral follicle count, and ovarian volume, suggesting that prediabetes may make ovaries more susceptible to PCOS-like changes. Additionally, lower anti-Müllerian hormone (AMH) levels in the prediabetes group indicated potential toxic effects of even mild hyperglycemia on the ovaries.
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