PCOS and Depression: Common Links and Potential Targets

October 2021 in “ Reproductive Sciences ”

Jagruti V. Kolhe, Abu Sufiyan Chhipa, Shital Butani, Vishal Chavda, Snehal Patel

polycystic ovary syndrome PCOS hormonal imbalances

TLDR Women with PCOS often experience depression and anxiety, affecting their quality of life.

The document reviewed the association between polycystic ovary syndrome (PCOS) and depression, highlighting the psychological distress experienced by women with PCOS. It discussed various studies that found a high prevalence of anxiety and depressive symptoms in women with PCOS, suggesting that these mental health issues were significant comorbidities. The review also explored potential physiological and psychosocial mechanisms linking PCOS to mood disorders, such as hormonal imbalances and maladaptive coping strategies. Additionally, it considered the impact of PCOS on quality of life and the importance of addressing mental health in the management of PCOS.

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Research cited in this study

8 / 8 results

research Anxiety, Depression, and Quality of Life in Women with Polycystic Ovarian Syndrome

60 citations , May 2018 in “Indian Journal of Psychological Medicine”

Women with PCOS often experience anxiety, depression, and a lower quality of life.

research Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study

26 citations , August 2014 in “Genetic Testing and Molecular Biomarkers”

High levels of TNF-α may contribute to obesity and insulin resistance in PCOS, but not due to the C850T genetic variation.

Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

research Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

1514 citations , December 2011 in “Fertility and sterility”

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

research Polycystic Ovary Syndrome in Adolescents

71 citations , November 2009 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

PCOS in teens is hard to diagnose, linked to genetics and lifestyle, and managed with weight loss and medication.

research Mood and Sexual Function in Polycystic Ovary Syndrome

68 citations , January 2008 in “Seminars in reproductive medicine”

Women with PCOS often feel stigmatized and have mood issues, which can lower their sexual satisfaction, but proper treatment and support can help.

research Polycystic Ovary Syndrome: Comprehensive Overview and Diagnostic Criteria

989 citations , August 2007 in “The Lancet”

PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.

research The Pathophysiology of Polycystic Ovary Syndrome

249 citations , November 2003 in “Clinical endocrinology”

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

research Polycystic Ovary Syndrome and Cardiovascular Disease: A Premature Association?

418 citations , June 2003 in “Endocrine Reviews”

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Related Research

4 / 4 results

research Correlation of Clinical and Biochemical Hyperandrogenism in Thai Women with Polycystic Ovary Syndrome

14 citations , February 2016 in “Journal of Obstetrics and Gynaecology Research”

Blood tests are needed to confirm high male hormone levels in women with PCOS, as physical signs alone are not reliable.

research Hyperandrogenism in Women: Polycystic Ovary Syndrome

3 citations , January 2012 in “Hanyang Medical Reviews”

The document concludes that more research is needed to create suitable diagnostic criteria and understand PCOS in Korean women, and genetics may allow for personalized treatment.

research Polycystic Ovary Syndrome and Acne

10 citations , January 2011 in “Skin therapy letter”

Women with PCOS often have acne because of high androgen levels, and the article reviewed how to treat this type of acne.

research Diagnosis of Hyperandrogenism: Clinical Criteria

85 citations , June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism”

The document concludes that hirsutism is the main sign for diagnosing hyperandrogenism, which requires a detailed patient history and physical exam.

PCOS and Depression: Common Links and Potential Targets

Research cited in this study

research Anxiety, Depression, and Quality of Life in Women with Polycystic Ovarian Syndrome

research Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study

research Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

research Polycystic Ovary Syndrome in Adolescents

research Mood and Sexual Function in Polycystic Ovary Syndrome

research Polycystic Ovary Syndrome: Comprehensive Overview and Diagnostic Criteria

research The Pathophysiology of Polycystic Ovary Syndrome

research Polycystic Ovary Syndrome and Cardiovascular Disease: A Premature Association?

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Related Research

research Correlation of Clinical and Biochemical Hyperandrogenism in Thai Women with Polycystic Ovary Syndrome

research Hyperandrogenism in Women: Polycystic Ovary Syndrome

research Polycystic Ovary Syndrome and Acne

research Diagnosis of Hyperandrogenism: Clinical Criteria