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In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.

This review discusses recent advancements in microneedle technology for hair loss treatment, highlighting their ability to enhance drug delivery and improve hair follicle survival in transplantation, while also exploring their potential integration with tissue engineering to address regeneration challenges.

This review highlights that skin organoids, advanced three-dimensional models mimicking human skin, are emerging as effective alternatives to traditional culture models and human skin, overcoming limitations of two-dimensional systems and ethical concerns, and are being increasingly used in areas like developmental biology and disease modeling.

This review discusses the regulatory roles of type 2 alarmin cytokines in skin immunity, focusing on their implications in host defense, chronic inflammation, and cancer, but reports no new clinical results.

This review discusses the various components essential for successful tissue engineering, such as cell sources, modification methods, and supportive matrices, and highlights the need for functional synergy without reporting new experimental results.

This review found significant progress in 3D bioprinting for surgery, noting advances in creating complex tissue constructs, while highlighting ongoing challenges like vascularization and integration with host tissue, emphasizing the need for further research and regulatory development.

In this study, researchers reviewed the progress and challenges in using hydrogels for 3D printing in biomedical applications, highlighting advancements in structural complexity, and identifying ongoing issues like resolution improvement, cell viability, and ethical concerns for clinical use.

This study demonstrated that human hair follicle stem cells can be efficiently differentiated into endothelial-like cells using VEGF and bFGF, suggesting their potential as a novel cell source for vascular tissue engineering.

In this study, researchers developed a method to efficiently derive contractile smooth muscle cells from human hair follicle stem cells using TGF-β1 and PDGF-BB, which may advance vascular tissue engineering.

This review highlights how natural compounds can enhance wound healing by influencing fibroblast behavior and discusses innovative biomimetic engineering and delivery methods. This source emphasizes combining traditional and modern approaches for effective and scar-free healing, while noting challenges in clinical translation.

This review discusses the medical and dental applications of polyhydroxyalkanoates (PHAs), highlighting their potential for improving drug delivery and providing biocompatible solutions for medical devices, but reports no new clinical results.

This review highlights the rapid advancements in 3D bioprinting techniques, emphasizing their role in enhancing regenerative therapy, drug delivery, and bioengineering applications while addressing current challenges in bioink formulation and bioprinting stability.

This review describes adipose tissue-derived therapies as promising for osteoarthritis, with potential to repair cartilage, reduce inflammation, and enhance joint function, highlighting advancements and their potential future applications.

This study developed a multifunctional core-shell fiber dressing that preserves platelet-rich plasma for 180 days, facilitating sustained growth factor release and improved wound healing.

This study developed a smart PVA-TPE/HA-AMP/SF/ALG wound dressing that shows promise in infected wound healing by providing bacterial resistance, promoting cell proliferation, and modulating inflammation through various signaling pathways, potentially reducing scar formation.

This review introduces a framework to integrate bioinspired conductive materials and advanced 3D/4D printing in regenerative medicine for dynamic, responsive tissue regeneration, emphasizing the potential of smart scaffolds to adapt to physiological cues.

This review outlines the design and engineering of multifunctional hydrogels, emphasizing their evolving biomedical applications, notably in controlled drug delivery, tissue support, and disease management, and discusses their potential for clinical translation.

This review covers the diverse clinical applications of platelet-rich plasma in regenerative medicine but provides no new clinical results.

This review discusses ongoing concerns and advancements in the use of gelatin as a biomaterial in tissue engineering, highlighting improved tissue mimicry through techniques like 3D bioprinting and suggesting a future focus on disease detection and diagnosis rather than treatment.

This review discusses recent advancements in the study and application of epidermal stem cells for wound healing and tissue engineering, without presenting new experimental findings.

In this review, biomaterial-based mechanical strategies were highlighted for their potential to enhance skin regeneration and promote scarless repair, though a comprehensive understanding of their underlying mechanisms is still needed for broader application.

This review highlights advancements in electrospun nanofibers, focusing on their potential applications in biomedical technologies, chemical and biological sensing, and energy harvesting within IoT devices.

This review highlights recent advancements in using nanotechnology for scar prevention and treatment, emphasizing the unique properties of nanomaterials in drug delivery and the challenges that remain in maximizing their potential for effective scar interventions.

This review discusses the design strategies and applications of long-acting polymeric microneedles, noting their potential to improve patient compliance and reduce side effects in chronic disease management, but reports no new experimental results.

This review describes bioengineering strategies to mimic the natural cell microenvironment in vitro, emphasizing the novel approach of using cell-synthesized extracellular matrix as a scaffold for engineering functional 3D tissues, while highlighting the limitations of exogenous scaffolds in tissue engineering.

This review discusses various types of stem cells used in regenerative medicine, including adult stem cells and induced pluripotent stem cells (iPSCs), and evaluates them based on their embryonic tissue origins to explore new therapeutic approaches.

This review discusses the history and development of keratin biomaterials for biomedical uses, highlighting their biological activity and biocompatibility, and provides no new research findings.

This article reviews follicular melanogenesis, detailing how melanin synthesis and its regulation in hair follicles depend on a complex interplay of cellular and molecular mechanisms, but reports no new clinical findings.

This study found that electrospun poly(ε-caprolactone)/poly(3-hydroxybutyrate) blend fibers demonstrated nanometric dimensions and promising properties for drug delivery, with curcumin release linked to fiber morphology and processing parameters.

This study found that bioengineered skin substitutes developed for 21 or 28 days effectively mimic native skin's ability to absorb UV radiation, suggesting suitability for treating severe skin defects.