17 citations
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May 1995 in “Anatomy and Embryology” This study found that treating neonatal mice with the neurotoxin 6-OHDA resulted in temporary hair loss and thinner skin compared to control mice, linking sympathetic neurons to hair growth and skin thickness.
July 2025 in “Avicenna Journal of Medicine” In this study, traditionally prepared ant oil reduced hair regrowth by about 50% in neonatal mice without causing skin irritation, suggesting its potential as a natural alternative for managing unwanted hair, although further research is needed to confirm these effects.
This study found that platelet-rich plasma improved the development and maturation of the skin and hair follicles in neonatal mice compared to a saline control.
15 citations
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July 2008 in “Journal of Dermatological Science” This study found that ephrin-A3 accelerates hair follicle development and increases hair follicle density in neonatal mice, suggesting its involvement in hair growth regulation.
This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.
July 2022 in “Journal of Investigative Dermatology” This study found that the transcription factor Lef1 is crucial for normal skin and hair development and wound healing, highlighting its role in regulating essential genes and pathways in papillary fibroblasts.
5 citations
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July 2018 in “Experimental Dermatology” In this study, researchers developed a relatively simple punch assay for regenerating hair follicles using mouse or human cells, finding efficient hair formation with mouse cells but low efficiency with human cells on reconstituted human skin.
This study found that type XVII collagen is crucial for regulating epidermal cells' proliferation in mice and may be a promising target for anti-aging skin treatments.
April 2010 in “Plastic and Reconstructive Surgery” This study demonstrated that multipotential cells grafted onto matrices successfully grew new hair in 92% of mice, suggesting potential future applications in hair restoration using this method.
5 citations
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October 2020 in “Journal of radiation research” The researchers found that exosome-like vesicles from irradiated cheek skin in neonatal mice may offer protective effects against hair follicle loss after high-dose radiation exposure.
This study found that in mice, type XVII collagen is essential for controlling epidermal cell proliferation through Wnt signaling, with its deficiency or altered distribution leading to skin hyperproliferation and aging-like changes.
1 citations
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July 2023 in “Journal of visualized experiments” This study presents an improved protocol for isolating and culturing whole neonatal cochlear explants, enabling detailed analysis of hair cells and spiral ganglion neuron cells while simplifying culture steps without sacrificing explant quality, and was successfully tested on mice and rat cochleas.
103 citations
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July 2001 in “Proceedings of the National Academy of Sciences” This study found that conditional expression of TGFβ1 in mice affects epidermal and hair follicle growth, with chronic expression causing severe alopecia and a negative feedback loop involving Smad7.
47 citations
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June 2012 in “Genes & Development” This study found that maternal consumption of a western diet in mice led to toxic milk production, causing inflammation and alopecia in nursing neonates due to Toll-like-receptor activation.
April 2014 in “The FASEB Journal” This study found that maternal hephaestin knockout in mice leads to neonatal hair loss, likely due to low iron levels in the mother's milk.
33 citations
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February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that overexpression of IGF-1 in transgenic mice stimulated increased vibrissa growth during the first neonatal hair cycle compared to their nontransgenic littermates.
24 citations
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April 2012 in “Developmental Biology” This animal study found that dermal papilla cells in hair follicles of chimeric mice can originate from various fibroblasts in the skin, challenging assumptions about their specific lineage.
5 citations
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January 2013 in “Cells Tissues Organs” This study found that activin B promotes the initiation and development of hair follicles in both cultured and neonatal mouse skin models.
This study found that activin B promotes the initiation and development of hair follicles in cultured and neonatal mice.
This study found that chronic UVR exposure in mice and humans leads to a permanent loss of papillary fibroblasts in the upper dermis, which is associated with changes in the extracellular matrix.
51 citations
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August 2012 in “Differentiation” This study found that penile and clitoral differentiation in mice is influenced by androgen exposure, with penile features developing postnatally requiring prenatal and ongoing androgen presence.
January 2012 in “Institutional Repositories DataBase (IRDB)” This study found that transplanting cell aggregates from mouse skin and lung mesenchymal cells can regenerate hair follicles in immunodeficient mice with skin wounds.
128 citations
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October 2011 in “Development” This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.
July 2024 in “Journal of Nanobiotechnology” This study found that dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by enhancing fibroblast activity and activating the Wnt/β-catenin signaling pathway in mice.
32 citations
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April 2017 in “Scientific Reports” This study found that 5% activated platelet-rich plasma significantly improved cell proliferation and hair-inductive ability of dermal papilla cells in vitro, and promoted hair follicle formation in mice.
9 citations
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August 2013 in “Journal of Tissue Engineering and Regenerative Medicine” In this study, neonatal murine skin-derived cells transplanted using a mini-chamber method successfully produced robust and normal hair, contrasting with human scalp follicles which did not achieve follicle reconstruction.
January 2012 in “Institutional Repositories DataBase (IRDB)” This study observed that cell aggregates derived from mouse skin and lung tissues may aid in hair follicle regeneration when transplanted into skin defects of immunodeficient mice.
30 citations
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October 1999 in “Differentiation” This study found that expression of certain mutant keratin genes in mice led to severe alopecia, suggesting a similar mechanism could cause hair loss in humans.
23 citations
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February 2020 in “PLOS genetics” This study found that biallelic LSS mutations lead to congenital hypotrichosis and cataracts, with each tissue-specific loss of function observed in mouse models.
16 citations
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October 2014 in “Cell death and disease” This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.