7 citations
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March 2021 in “Evidence-based Complementary and Alternative Medicine” This study found that Nelumbinis Semen extract may promote hair growth and reduce hair loss by increasing VEGF and IGF-1 expression and decreasing TGF-β1 in human dermal papilla cells and mice.
This study found that a complex extract of Polygonatum sibiricum and Nelumbinis semen improved menopause symptoms in an ovariectomized rat model by enhancing blood lipid metabolism and reducing osteoporosis, without increasing risks of side effects like endometriosis, unlike conventional hormone-replacement therapy.
19 citations
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October 2018 in “Medicine” In this meta-analysis, researchers found that moxibustion combined with oriental herbal medicine may improve pregnancy rates and other outcomes in women with polycystic ovary syndrome compared to western medication alone; however, the evidence is limited by the poor quality of included studies.
January 2025 in “International Journal of Biological Innovations” This review article discusses the potential benefits of phytochemicals in hair care, highlighting their ability to improve scalp health, reduce dandruff, and promote hair growth, while emphasizing their safety and minimal side effects compared to conventional therapies.
125 citations
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May 2019 in “Phytomedicine” This review discusses the historical development, mechanisms of action, and potential new clinical applications of the drug cepharanthine, highlighting its multi-faceted pharmacological properties; it reports no new clinical results.
41 citations
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June 2024 in “Journal of Cellular and Molecular Medicine” This study reviews how oxidative stress affects hair follicle development and hair growth, discusses antioxidant-based treatments for hair loss, and evaluates natural antioxidant products that promote hair growth, emphasizing the need for further research due to existing limitations.
7 citations
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December 2021 in “Pharmaceutics” This review examines the anti-alopecia effects of plant-derived phytochemicals and their mechanisms for promoting hair growth, but it reports no new clinical findings.
2 citations
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July 2023 in “International Journal of Molecular Sciences” This study found that applying a formulation derived from Bacopa procumbens significantly promoted hair growth, pigmentation, and follicular cycle acceleration in mice compared to minoxidil, potentially offering a new therapeutic approach for hair health.
September 2025 in “Current Issues in Molecular Biology” This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.
This study found that recombinant human type XVII collagen (rhCOL17A1) promotes hair growth by activating the Wnt/β-catenin and SHH/GLI signaling pathways and increasing type XVII collagen expression, with significant effects observed in both cell and mouse models.
July 2024 in “International Journal of Molecular Sciences” In this study, Nigella sativa oil was found to promote dermal papilla cell proliferation and may reduce oxidative stress, suggesting its potential as a hair loss intervention.
May 2024 in “Molecules/Molecules online/Molecules annual” This narrative review reports that well-selected plant extracts and their active compounds may improve hair health by promoting hair growth and preventing hair loss, potentially aiding in developing targeted therapies for alopecia.
July 2023 in “Research journal of pharmacy and technology” In this study on male rabbits, a hair tonic formulated with delipidated ethanol extract of Capsicum frutescens L. leaves at concentrations of 5%, 10%, and 20% promoted hair growth more effectively than a placebo and similar to 2% Minoxidil at the highest concentration.
October 2022 in “International Journal of Molecular Sciences” This study found that collagen peptides from Mozambique tilapia significantly promoted hair regrowth and increased the proliferation of hair growth factors in vitro and in vivo, suggesting potential as supplements for hair loss prevention.
9 citations
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August 2024 in “Frontiers in Pharmacology” This review evaluates the potential of natural products and medicinal plants for myocardial infarction treatment, highlighting their therapeutic promise and mechanisms such as reducing oxidative stress and inflammation, but reports no new clinical results.
This review concludes that the global literature supports the efficacy and safety of lipidosterolic extract of Serenoa repens in treating lower urinary tract symptoms, comparable to alpha-blockers and 5α-reductase inhibitors.
January 2019 in “Indian Journal of Dermatology, Venereology and Leprology” 14 citations
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June 2014 in “World Journal of Urology” This study found that the herbal combination PRO 160/120 significantly improved nocturnal voiding frequency in patients with moderate-to-severe LUTS/BPH compared to placebo, with similar effectiveness to tamsulosin and finasteride.
3 citations
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August 2021 in “Uro” This review concludes that global literature supports the lipidosterolic extract of Serenoa repens as efficacious and safe for treating lower urinary tract symptoms, with some studies showing equivalence to common pharmacologic agents.
January 2025 in “Indian Journal of Animal Research” This study observed that herbal feed supplementation in Frieswal breeding bulls improved semen volume and motility, while significantly lowering dihydrotestosterone levels, suggesting a potential mechanism for enhancing semen quality.
2 citations
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July 2021 in “Uro” This review discusses the efficacy of the lipidosterolic extract of Serenoa repens for treating lower urinary tract symptoms and reports no new clinical results; the authors propose further examination of the existing literature and guidelines.
2 citations
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August 2021 in “The Journal of Urology” This study reported that seminal vesiculoscopy combined with transurethral resection of ejaculatory ducts and balloon dilation effectively resolved hematospermia and improved symptoms in a patient whose condition was unresponsive to medical treatments.
1 citations
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September 2025 in “Archivio Italiano di Urologia e Andrologia” In this study, the combination of Serenoa repens extract with Phenolmicin P3 and Bosexil suppositories significantly improved lower urinary tract symptoms and decreased PSA levels in patients with benign prostatic obstruction-related symptoms.
February 2022 in “World Journal Of Advanced Research and Reviews” This study found that Peperomia pellucida plant extract may benefit hair growth, male libido, male fertility, and renal cell recovery.
54 citations
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September 2002 in “Annals of Pharmacotherapy” This review discusses various herbal therapies, such as Serenoa repens and Pygeum africanum, for treating benign prostatic hyperplasia, noting their potential but highlighting unresolved questions about their efficacy and safety.
1 citations
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September 2023 in “Prostate International” In this study, a 12-week treatment with Angelicae Gigantis Radix and Glycyrrhizae Radix complex was well tolerated and showed therapeutic effects on moderate lower urinary tract symptoms in men.
1 citations
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January 2020 in “Recent Research in Genetics and Genomics/Recent Research in Genetics and Genomics ” In this study, high doses of Lepidium sativum seeds extract were reported to cause toxicity and tissue damage in animals, suggesting the need for careful use under medical supervision.
3 citations
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January 2019 in “Therapeutic advances in urology” This review concluded that WS PRO 160 I 120 mg, a herbal preparation, may be an effective and safer alternative to standard drugs for treating lower urinary tract symptoms in men with benign prostatic hyperplasia.
January 2026 in “Food and Nutrition Sciences” This randomized, placebo-controlled trial reported that USPlus PRO saw palmetto extract significantly improved lower urinary tract symptoms, including voiding, incomplete emptying, and weak stream, as well as sexual function in males over 12 weeks, while maintaining a favorable safety profile.
February 2026 in “Chinese Medicine” Natural products might help treat hair greying.