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This study introduces a co-design framework using finite element analysis to optimize separable bubble microneedles, demonstrating enhanced transdermal and sublingual drug delivery in preclinical models. In vivo results showed faster hair regrowth and glucose lowering in animals, indicating potential improvements over traditional methods.

This article discusses the potential of novel microneedle transdermal systems for enhanced drug and vaccine delivery through the skin, but reports no clinical results and emphasizes ongoing trials.

This study found that pulmonary delivery of cepharanthine significantly improved bioavailability and may provide protective effects against pulmonary fibrosis related to COVID-19 infection in a rat model.

This review highlights the potential of microneedles as a pediatric-friendly method for delivering proteins, vaccines, and diagnostics transdermally, noting their ability to penetrate the skin's barrier and suggesting future applications in other parts of the body.

This study reported that a colistin sulfate-loaded nanoemulgel showed improved antimicrobial activity and skin permeability compared to a CS solution, suggesting a potential new approach for treating severe infections caused by multidrug-resistant bacteria.

This source describes the potential benefits of a nanoemulgel delivery system for enhancing the use of lipophilic drugs, improving patient compliance, and expanding treatment options for various conditions, including acne, arthritis-related inflammation, and Parkinson's disease, while also offering sunburn protection in cosmetic applications.

This study investigated the use of methylene blue in a niosomal hydrogel for photodynamic treatment of acne and found that it led to significant improvement in inflammation compared to IPL treatment.

This study found that nanoparticles containing minoxidil and betamethasone improved drug delivery to hair follicles, with lipidic nanoparticles significantly enhancing minoxidil and betamethasone penetration compared to control, making them a promising option for alopecia areata treatment with reduced side effects.

In this study, cetirizine hydrochloride was formulated into niosomal and cubosomal gels, showing potential for off-label use in treating androgenic alopecia due to effective skin permeation and acceptable safety profiles; cubosomal gels exhibited superior permeation compared to niosomal gels.

In this preliminary study, topical treatment with oxygen-carrying micro/nanobubbles hastened the healing of full-thickness burn wounds in a rodent model, compared to saline-treated controls.

Minoxidil sulfate, delivered through iontophoresis, can be used to treat hair loss.

In this study, carbon dots derived from dandelion herb demonstrated significant antibacterial and biofilm-disrupting capabilities, promoting wound healing in a mouse model infected with S. aureus, while also showing excellent biocompatibility and the ability to modulate reactive oxygen species.

This study developed dissolving microneedles using specific polymers for transdermal delivery of rizatriptan benzoate, demonstrating improved drug skin penetration and significant alleviation of migraine symptoms in vivo compared to passive diffusion, suggesting potential advantages over conventional treatment methods for acute migraine.

In this study, topical nitroglycerine spray successfully prevented impending necrosis in 94% of hair transplant cases showing signs of vascular distress.

This case report describes how nitroglycerin (sublingual) was used to prevent further scalp necrosis during hair restoration surgery, particularly in a patient experiencing early necrosis linked to local anesthetics with epinephrine.

This study found that cetirizine-loaded niosomal gels demonstrated superior skin deposition and retention compared to plain cetirizine gel, suggesting potential for improved topical management of alopecia.

In this study, microneedling combined with bleomycin treatment for plantar warts improved the response time and reduced the number of treatment sessions needed, with a relapse rate similar to other injection-based methods.

In this study, researchers optimized fast-dissolving tablets of nifedipine using a systematic approach, resulting in formulations that demonstrated rapid disintegration, enhanced dissolution profiles, and improved solubility, potentially improving oral delivery for patients requiring poorly soluble antihypertensive medication.

The flutamide-loaded hydrogel is a promising, skin-friendly treatment for acne and hair loss, potentially requiring less frequent application.

This study highlights the potential of nanoemulgel, a nano-lipoidal gel formulation, as an effective method for delivering topical drugs, especially for BCS class II/IV pharmaceuticals, and emphasizes the need for thorough toxicological evaluations due to changes in delivery methods.

This work explores using a liquid crystalline phase to stabilize benzoyl peroxide nanosuspensions, suggesting a promising method to potentially reduce the side effects of acne treatments.

This article proposes that transnasal evaporative cooling could advance understanding of various physiological phenomena, but reports no new clinical results; potential research directions are suggested for this concept.

Tavaborole is a safe and effective toenail fungus treatment, with the 5% solution being the best option.

This study focused on developing a nanoemulsion-based gel for delivering minoxidil, aiming to enhance its contact time with the scalp and potentially improve skin absorption compared to conventional topical solutions.

This study developed a Neusilin® US2-based solid self-nanoemulsifying drug delivery system for finasteride that showed improved stability and drug delivery, with complete dissolution comparable to standard Propecia® tablets.

This review discusses recent advances in droplet microfluidics for chip-based technologies such as single-cell analysis, small-scale cell cultures, and high-throughput drug screening, and it reports no new results.

This study presents the design of an autonomous bioregeneration chamber that aims to extend human lifespan to 130-150 years by optimizing biological and environmental conditions, suggesting that a longer healthspan is possible through technological, nutritional, and socio-economic interventions.