Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection

    April 2022 in “ Molecules ”
    Jian Li, Guangrui Chen, Zhiyun Meng … Guifang Dou
    Studysummary This study found that pulmonary delivery of cepharanthine significantly improved bioavailability and may provide protective effects against pulmonary fibrosis related to COVID-19 infection in a rat model.
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    Research cited in this study 5

    1. Evaluating Cepharanthine Analogues as Natural Drugs Against SARS-CoV-2 FEBS Open Bio · 2021
    2. Structural Insights Into SARS-CoV-2 Spike Protein and Its Natural Mutants Found in Mexican Population Scientific Reports · 2021
    3. Cepharanthine-Loaded Nanoparticles Coated With Macrophage Membranes for Lung Inflammation Therapy Drug Delivery · 2021
    4. Cepharanthine: A Review of the Antiviral Potential of a Japanese-Approved Alopecia Drug in COVID-19 Pharmacological Reports · 2020
    5. Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties, and Medical Applications Phytomedicine · 2019