The Brief Overview, Antivirus and Anti-SARS-CoV-2 Activity, Quantitative Methods, and Pharmacokinetics of Cepharanthine: A Potential Small-Molecule Drug Against COVID-19

    July 2023 in “ Frontiers in Pharmacology ”
    Binbin Xia, Zheng Li, Yali Li … Hua Cheng
    Studysummary This review highlights cepharanthine as a promising candidate for COVID-19 treatment due to its antiviral activity against SARS-CoV-2 and favorable pharmacokinetic and safety profile, but reports no new clinical results.
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    Research cited in this study 10

    1. The Antiviral Activity of a Small Molecule Drug Targeting the NSP1-Ribosome Complex Against Omicron, Especially in Elderly Patients Frontiers in Cellular and Infection Microbiology · 2023
    2. The Common Regulatory Pathway of COVID-19 and Multiple Inflammatory Diseases and the Molecular Mechanism of Cepharanthine in the Treatment of COVID-19 Frontiers in Pharmacology · 2022
    3. Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection Molecules · 2022
    4. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021
    5. Evaluating Cepharanthine Analogues as Natural Drugs Against SARS-CoV-2 FEBS Open Bio · 2021
    6. Comparison of Viral RNA–Host Protein Interactomes Across Pathogenic RNA Viruses Informs Rapid Antiviral Drug Discovery for SARS-CoV-2 Cell Research · 2021
    7. Preparation and Evaluation of Self-Emulsifying Drug Delivery System of Cepharanthine AAPS PharmSciTech · 2021
    8. Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase bioRxiv (Cold Spring Harbor Laboratory) · 2020
    9. Cepharanthine: A Review of the Antiviral Potential of a Japanese-Approved Alopecia Drug in COVID-19 Pharmacological Reports · 2020
    10. Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties, and Medical Applications Phytomedicine · 2019