August 2025 in “Arabixiv (OSF Preprints)” This study suggests that male pattern baldness is primarily caused by heat stress in the brain rather than DHT toxicity, and personal experiments with menthol cooling have shown significant reduction in hair loss.
This study found that scalp cooling effectively prevented visible hair loss in over half of patients undergoing highly alopecia-inducing chemotherapy, yet cognitive appraisal of the treatment had a more significant impact on quality of life than the actual degree of hair retention.
7 citations
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December 2015 in “Journal of thermal biology” This study used numerical models to explore the cooling power required by different scalp cooling devices to prevent chemotherapy-induced hair loss, finding that coolant temperature significantly influences scalp tissue temperatures.
5 citations
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September 2024 in “Journal of Clinical Medicine” This article reviews the pathophysiology of chemotherapy-induced alopecia and reports that scalp cooling can reduce hair loss by 50% in patients with early breast cancer receiving chemotherapy, without compromising survival or increasing scalp metastasis risk.
June 2024 in “Journal of clinical oncology” This study found that sensor-controlled scalp cooling prevented visible hair loss in 53% of breast cancer patients undergoing chemotherapy, with greater hair density and absence of comorbidities enhancing its efficacy, also improving patients' quality of life without increasing scalp metastasis risk.