Niosomal Versus Cubosomal Gels of Cetirizine Hydrochloride: Cost-Effective Permeation Enhancement for Potential Transdermal Application

    October 2025 in “ Pharmaceutical Development and Technology ”
    Esraa M. Elboushy, Azza A. Hasan, Gehan F. Balata, Noura G. Eissa
    Studysummary In this study, cetirizine hydrochloride was formulated into niosomal and cubosomal gels, showing potential for off-label use in treating androgenic alopecia due to effective skin permeation and acceptable safety profiles; cubosomal gels exhibited superior permeation compared to niosomal gels.
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    Research cited in this study 9

    1. Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications Journal of Lipids · 2024
    2. Formulation Optimization, In Vitro and In Vivo Evaluation of Niosomal Nanocarriers for Enhanced Topical Delivery of Cetirizine Saudi Pharmaceutical Journal · 2023
    3. Hair Regrowth Boosting Via Minoxidil Cubosomes: Formulation Development, In Vivo Hair Regrowth Evaluation, Histopathological Examination, and Confocal Laser Microscopy Imaging International Journal of Pharmaceutics · 2023
    4. Niosomal And Ethosomal Gels: A Comparative In Vitro And Ex Vivo Evaluation For Repurposing Of Spironolactone Journal of Drug Delivery Science and Technology · 2022
    5. Coenzyme Q10 Phospholipidic Vesicular Formulations for Treatment of Androgenic Alopecia: Ex Vivo Permeation and Clinical Appraisal Expert Opinion on Drug Delivery · 2021
    6. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-Blind Controlled Study Journal of Pharmacy and Pharmaceutical Sciences · 2021
    7. Therapeutic Implications of Topical Cetirizine 1% in Treatment of Male Androgenetic Alopecia: A Case-Controlled Study Journal of Cosmetic Dermatology · 2021
    8. Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils Expert Opinion on Drug Delivery · 2018
    9. A Preliminary Study on Topical Cetirizine in the Therapeutic Management of Androgenetic Alopecia Journal of Dermatological Treatment · 2017