A Quantitative Assessment of Wound Healing With Oxygenated Micro/Nanobubbles in a Preclinical Burn Model

    September 2021 in “ Annals of Plastic Surgery ”
    Lohrasb R. Sayadi, Rebecca A. Rowland, Alexandra Naides, Luke Tomlinson, Adrien Ponticorvo, Anthony J. Durkin, Alan D. Widgerow
    TLDR Oxygenated micro/nanobubbles speed up burn wound healing in rats.
    The study "A Quantitative Assessment of Wound Healing With Oxygenated Micro/Nanobubbles in a Preclinical Burn Model" demonstrated that treatment with oxygenated micro/nanobubbles (MNB(O2)) significantly accelerated burn wound healing in a rat model (n=6). Key findings included enhanced re-epithelialization, increased collagen deposition, improved collagen organization, and reduced inflammation in the treated wounds compared to controls. Histological analysis showed that MNB(O2) treated wounds reached the remodeling phase by day 28, unlike the control group. Despite limitations such as small sample size, the results suggest that MNB(O2) could be a promising therapeutic approach for improving burn wound healing and warrant further studies.
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