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In this study, researchers developed microparticle-embedded gas-propelled microneedles that showed higher drug loading and transdermal delivery efficiency compared to traditional microneedles.

This review discusses using extracellular vesicles as less invasive surrogates for assessing drug-metabolizing enzymes and transporters, suggesting potential advancements in precision therapy, but reports no new clinical results.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

This study introduced hydrogel microneedles loaded with palladium nanoparticles, which utilize the inherent cytotoxicity of polyethyleneimine to enhance the effectiveness of doxorubicin in treating melanoma, achieving a tumor inhibition rate of up to 98% in a murine model.

This article outlines how nanotechnology strategies, including phospholipid-based nanocarriers like liposomes, could enhance the effectiveness and skin tolerability of acne treatments, aiming to reduce side effects and improve patient compliance in managing acne vulgaris.

This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.

This study investigated the physicochemical properties of polystyrene-b-poly(acrylic acid) nanovesicles coated with modified chitosans, finding that they can effectively control surface charge and potentially serve as drug delivery carriers with a 50.7% encapsulation efficiency for minoxidil.

This review highlights the therapeutic potential of plant-derived exosomes, noting their larger size compared to animal-derived exosomes and usefulness in targeted drug delivery and inter-kingdom communication. It summarizes existing research on their biogenesis, characterization, and engineering for drug delivery, indicating significant opportunities for biotechnological advancements.

This review summarizes the potential of nanostructured lipid carriers in drug delivery systems, highlighting their promise in enhancing the stability and skin penetration of anti-aging cosmetics.

This study developed multifunctional microneedle patches with CTB nanozymes that successfully eradicated MRSA infections in wounds by combining near-infrared laser-induced nitric oxide release and local hyperthermia, while also regulating oxidative stress, inflammation, and angiogenesis through specific signaling pathways.

This study reported that a colistin sulfate-loaded nanoemulgel showed improved antimicrobial activity and skin permeability compared to a CS solution, suggesting a potential new approach for treating severe infections caused by multidrug-resistant bacteria.

This review discusses advancements in the use of microneedle arrays and nanoparticles for transdermal delivery of therapeutics, noting challenges in overcoming the skin barrier and summarizing recent clinical trial achievements in areas like cancer therapy and gene therapy.

This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.

This study found that biodegradable hyperbranched polyesters improved the solubility and loading capacity of hydrophobic drugs, with complete pyrene release achieved in 16 days under enzymatic conditions.

This chapter reviews nanotechnology in cosmetics, detailing various formulations, performance assessment methods, and evolving regulations, while discussing safety, stability, and effectiveness concerns; it reports no new experimental results.

This study concluded that a liquid serum formulation delivered two fluorescent dyes to deeper follicular regions more effectively than nanoparticle systems.

This review discusses the potential of nanocarriers to enhance transdermal drug delivery and the combination of these carriers with physical methods, but it reports no new experimental results.

This study reported the development of pH-responsive nanoparticles that effectively deliver vancomycin in a controlled manner, demonstrated enhanced antibacterial activity, and showed promise for clinical applications by targeting bacterial infection sites with programmable drug release.

Dissolvable microneedles are a promising, painless method for effective skin treatments.

This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.

Formulation F1 is the best for delivering finasteride effectively.

This study examines the role of nanotechnology in cosmetics, highlighting its benefits in improving ingredient solubility and stability, but also noting challenges such as cost, shelf life, and safety concerns, along with regulatory complexities, particularly in harmonizing global legislation.

This study found that niosomal aminexil was more clinically effective for hair growth than conventional aminexil solutions, and that niosomes facilitated aminexil penetration through rat skin without propylene glycol.

This review highlights recent advancements in using nanotechnology to improve the function and delivery of PROTAC drugs, despite existing challenges like low solubility and poor permeability, aiming to enhance their potential in disease treatment.

This study reported that ultrafine gelatin nanoparticles produced by a modified desolvation technique offer advantages for dermal drug delivery, including smaller particle size, higher drug loading, and faster release compared to traditional gelatin nanoparticles.

In this study, ethosomes were found to significantly enhance the transdermal penetration and skin accumulation of finasteride compared to liposomes and other control solutions.

This review discusses the potential of bacterial extracellular vesicles in regenerative medicine, highlighting their advantages in addressing current EV challenges, and provides strategies for optimizing their preparation; it reports no new clinical results.