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This study found that chronic UVR exposure in mice and humans leads to a permanent loss of papillary fibroblasts in the upper dermis, which is associated with changes in the extracellular matrix.

This study explored the role of Twist2 in fetal wound healing in embryonic mice, observing that its expression was vital for scarless regeneration and normal hair follicle formation; Twist2 knockdown led to visible scars and defective follicle formation.

In this study, researchers found that the protein Twist2 plays a crucial role in scarless wound healing in early embryonic mouse skins, with its knockdown leading to visible scarring and defective hair follicle formation, suggesting potential therapeutic targets for reducing scars and promoting regeneration.

This study found that Forskolin-loaded carboxymethyl chitosan-silk nanofiber hydrogels promoted wound healing by accelerating wound closure, enhancing neovascularization, and supporting hair follicle regeneration, while also being non-toxic and encouraging the proliferation of certain cell types.

This study found that tissue-engineered skin using mouse fibroblasts successfully supported hair growth after grafting, but similar success was not observed using human fibroblast-derived tissue.

This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.

This study found that CXCL12+ fibroblast subsets in mouse skin play a critical role in recruiting neutrophils and defending against S. aureus infection, with similar fibroblast activity observed in human psoriatic skin.

This review discusses the heterogeneity of dermal fibroblasts in healthy mouse and human skin and reports no clinical results; the authors highlight potential insights into physiological and pathological wound healing.

This study suggests that targeting the tumor stroma to promote the formation of dermal condensates may offer a novel approach to treating basal cell carcinoma.

In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.

Fibroblasts can be turned into melanocytes for potential skin treatments.

This study observed that in mouse fetuses, reticular contraction by actomyosin is involved in dermal regeneration, and differences in actin and α-SMA localization may determine the switch between regeneration and scar formation, suggesting potential insights for wound regeneration therapy.

In this study, mouse amnion epithelium was successfully transformed into skin and hair follicles when associated with hair-forming dermis, revealing the necessity of specific influences for follicle formation.

This review discusses the use of human-to-mouse xenografting to study human skin processes in vivo, highlighting its importance for understanding skin regeneration and pathology while identifying knowledge gaps and challenges in applying these findings to human skin.

This study developed a tissue-engineered model of innervated skin, allowing for examination of how epidermis and capillaries affect nerve growth and offering a tool for further research on skin-related processes.

In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.

This review explores fibroblast heterogeneity in the mammalian dermis and suggests potential therapeutic applications by targeting fibroblast subtypes, but reports no new experimental results.

This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.

This study identified at least four distinct fibroblast populations in adult human skin, each with unique functional properties, suggesting potential therapeutic applications for wound healing and fibrosis-related diseases.

This study suggests that human skin contains distinct fibroblast subsets with unique expression profiles and functions, which can be isolated to investigate their role in skin pathogenesis.

This review examines the diversity and role of stem cells in the adult dermis, noting a lack of precise understanding about their hierarchy and relationship to dermal fibroblast subpopulations, and reports no new results.

This study found that the loss of papillary fibroblasts in the skin due to UV radiation is mainly caused by an uncontrolled inflammatory response, with T cells helping fibroblast survival.

This study found that in stretch-mediated tissue expansion, fibroblasts adopt an embryonic-like, low-collagen state that enhances epidermal stem cell renewal, supporting coordinated skin expansion crucial for reconstructive surgeries.

This study found that UV radiation-induced fibroblast depletion in the skin is primarily due to a deregulated inflammatory response, with T cells aiding fibroblast survival under stress.

E13 fetal mouse fibroblast vesicles may help reduce scarring.

This study identified a gene expression signature in mouse embryonic dermal fibroblasts that depends on Wnt/β-catenin activity, potentially influencing dermal fibroblast identity and function.

The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.

In this study, mouse hair follicle stem cells cultured in mouse embryonic fibroblast/keratinocyte serum-free medium exhibited the highest proliferative ability and stronger osteogenic differentiation potential, similar to hair follicle dermal papilla cells.

This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin.

Mechanical stretching can improve or hinder skin regeneration depending on duration.