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This study found that carvone, a plant-derived compound, decreases melanin content and inhibits melanoma cell proliferation through the cAMP pathway, suggesting potential benefits for treating melanomas and other hyperpigmentation disorders.

In this study, researchers measured the solubility of Minoxidil in supercritical CO₂ under various temperature and pressure conditions and created models to estimate solubility based on different predictive approaches.

This study found that high-dose minoxidil, a potassium channel opener, may protect neuronal tissue from damage following transient focal cerebral ischemia in mice.

This study introduced a pre-formal ontology matching approach using 39 identified dimensions to integrate drug information, improving database normalization and supporting complex use cases.

The eucalyptus oil system improved skin delivery of hormones, but safety concerns remain.

This study found that PK11195 treatment weakened exploratory behavior in two strains of mice, while finasteride and indomethacin decreased exploration in laboratory rodents regardless of species.

This study found that subcutaneous injection of medroxyprogesterone acetate was more effective than intramuscular or topical treatments in reducing hair diameter for hirsute females.

This study developed a precise and sensitive HPLC-MS/MS method for analyzing the pharmacokinetics of perospirone hydrochloride in human plasma, establishing it as suitable for clinical studies.

This review discusses the biologically active compounds in Maxillariinae orchids, highlighting 62 semiochemicals with medical potential, but reports no new clinical findings.

This study reported that while no synthesized compounds surpassed finasteride in 5α-reductase inhibitory activity, certain 4-azasteroid-2-oximes exhibited notable inhibition.

This article reviews the medicinal uses of sweet violet in traditional Persian medicine, highlighting its benefits for conditions like coughing in asthmatic patients, constipation, insomnia, and allergic rhinitis, while noting no special side effects at therapeutic doses.

This review discusses adverse reactions to antihelminthic drugs and highlights that levamisole, a common street cocaine adulterant, can cause serious side effects, including skin necrosis and vasculitis.

This review discusses the role of neuro(active)steroids, particularly those in the 5α reductase pathway, in modulating dopamine signaling and their impact on neuropsychiatric disorders characterized by dopamine imbalances, including addiction, schizophrenia, and Parkinson's Disease.

In this study, withdrawal from progesterone and treatment with finasteride were associated with increased signs of depression-like behavior in female mice, suggesting decreased allopregnanolone levels may play a role.

This review found that oral methotrexate plus oral prednisone may improve disease activity or damage in juvenile active morphea compared to placebo plus prednisone, but adverse events may slightly increase.

This case report describes two postmenopausal women with Parkinson's disease who experienced reversible hair loss after using the dopamine agonists pramipexole and ropinirole.

This study found that minoxidil is bioactivated through sulfation by the phenol-sulfating form of phenol sulfotransferase in human liver.

This study hypothesized that finasteride administration may increase stress-induced amphetamine locomotor sensitization due to its impact on brain reward systems involving the neurosteroid allopregnanolone.

The conclusion is that a new method can measure caffeine and drugs in hair, finding caffeine abusers have 70 times more caffeine than normal, with a proposed cut-off value for abuse.

This article reviews the historical development of pharmacology up to the mid-20th century and outlines its transition from a support role in therapeutics to a distinct scientific discipline, but reports no new findings.

This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.

Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.

This study found that low-intensity exercise improved pain relief in aged rats through increased brain allopregnanolone levels, while high-intensity exercise was effective in both adult and aged rats via a different mechanism.

This study found that several new pregnane derivatives, especially steroids 16 and 19, demonstrated higher antiandrogenic activity on male hamster models than the commonly used finasteride.

This study found that PRL-1-overexpressing PD-MSCs reduced adipogenesis in orbital fibroblasts from Graves' ophthalmopathy patients by secreting IGFBPs and modulating the FAK pathway.

This study identified that Mangkokan leaf extracts contain active compounds such as alkaloids, flavonoids, steroids, tannins, phenols, and saponins, using different solvents and FTIR analysis.

This study found that two novel nonsteroidal derivatives inhibited specific enzymes in vitro and in vivo, leading to dihydrotestosterone accumulation in androgen-dependent glands, suggesting potential therapeutic use for mood improvement in the elderly.

This study found that topical application of Morinda pubescens fruit extract significantly accelerated wound healing and hair regrowth in rats compared to controls, with complete wound contraction and new hair growth observed in treated animals.

In this study, researchers found that the bioactive lipid sphingosine 1-phosphate and its receptor, S1PR3, are essential for regulating mechanical pain sensitivity in mice.

This study found that neurosteroids can reorganize GABA A receptors in mice, mimicking ovarian cycle changes, with the process being mediated by neurosteroid levels rather than direct hormone receptor activation.