Study on Pharmacokinetics and Determination of Perospirone in Human Plasma by HPLC-MS/MS

    January 2013 in “ Chinese Journal of Hospital Pharmacy ”
    Xuehua Jiang
    TLDR A reliable method was developed to measure perospirone levels in human plasma for clinical use.
    The study developed a sensitive and accurate HPLC-MS/MS method to determine the pharmacokinetics of perospirone in human plasma. The method involved liquid-liquid extraction and used finasteride as an internal standard. The pharmacokinetic study was conducted after single and multiple administrations of 8 mg and a single administration of 16 mg perospirone hydrochloride tablets. Results showed a linear range of 0.1-30 μg·L-1 with a detection limit of 0.1 μg·L-1. The concentration-time data fitted a two-compartment model, indicating a linear kinetic process within the tested dose range. The method was deemed suitable for clinical pharmacokinetic studies of perospirone hydrochloride tablets.
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