30 citations
,
September 2004 in “Experimental Dermatology” This study found that minoxidil did not significantly increase hair shaft elongation in ex vivo human hair follicle culture, questioning the suitability of this method for studying its hair-growth-promoting effects.
27 citations
,
March 2012 in “Dermatologic Surgery” This study found that finasteride treatment reduced caspase-1 expression, suggesting that androgens may influence immune processes in the hair cycle of androgenetic alopecia.
25 citations
,
May 2014 in “Facial Plastic Surgery” In this study, intradermal injections of autologous platelet-rich fibrin matrix significantly increased hair density in patients with androgenetic alopecia at 2 and 3 months after initial treatment.
25 citations
,
January 2002 in “Folia Pharmacologica Japonica” This article reviews the proposed mechanism of minoxidil in treating androgenetic alopecia, suggesting it may prolong the anagen phase by modulating cell growth factors and vascular activity, but reports no new results.
24 citations
,
March 2011 in “British Journal of Dermatology” This study found evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia.
17 citations
,
January 2010 in “PubMed” This review explores factors affecting graft growth and survival in hair restoration, emphasizing the importance of fundamental care practices while considering advanced storage solutions and additives, but reports no new findings.
17 citations
,
December 2004 in “The Journal of Men's Health & Gender” This article discusses the role of androgens in hair follicle changes, explaining how dihydrotestosterone contributes to hair thinning on the scalp, while promoting thicker facial hair in men, and reports no new clinical results.
14 citations
,
September 2016 in “Journal of Cutaneous Pathology” This review discusses the classification and diagnosis of primary scalp alopecia, focusing on scarring and non-scarring types, and reports no new clinical results; it emphasizes simplified diagnostic pathways and tissue processing techniques.
11 citations
,
November 2015 in “Skin Research and Technology” This study found that individuals with patterned hair loss, both male and female, showed a slower linear hair growth rate compared to controls with hair of equal thickness.
8 citations
,
April 2024 in “Cureus” This review compares the CO2 and Er:YAG laser treatments for acne scars, noting that while CO2 lasers offer deeper tissue penetration for severe scars, Er:YAG lasers pose a lower risk of post-inflammatory hyperpigmentation, and recommends personalizing treatments and considering combination therapies.
7 citations
,
September 2014 in “European Journal of Dermatology” This study found a significant positive correlation between hair thickness and growth rate, with a notably slower growth rate observed in men with male pattern hair loss compared to healthy controls.
6 citations
,
June 2019 in “Skin Research and Technology” In this study, finasteride treatment for two years did not significantly reverse miniaturized hair follicles in men with male pattern hair loss, challenging the "reversal hypothesis" as 79 out of 113 miniaturized hairs remained unchanged.
3 citations
,
January 2019 in “Skin appendage disorders” This case report describes a patient with primary cutaneous follicle center lymphoma who developed an alopecic atrophic patch potentially due to pressure, following rituximab treatment.
3 citations
,
January 2018 in “İstanbul Kuzey Klinikleri” This study found that 37.4% of high-school students in rural Eskisehir had alopecia, with affected students experiencing poorer health-related quality of life, particularly in general health perception, vitality, and mental health.
3 citations
,
February 2016 in “Nature Biotechnology” New drug shows promise for better hair growth in baldness treatment.
3 citations
,
October 2007 in “Expert Review of Dermatology” This review discusses the biological and cosmetic aspects of hair aging and reports no new clinical results; it highlights current treatments and future research directions to address both aging factors.
3 citations
,
November 1999 in “Journal of Cutaneous Medicine and Surgery” Examining scalp biopsies in different ways helps better diagnose hair loss types.
1 citations
,
January 2025 in “BIO Integration” This review highlights that the combination of ultrasound and microneedles can enhance transdermal drug delivery by using physical and energy-driven mechanisms to improve drug penetration into deeper skin layers, with implications for precision medicine and chronic disease treatments.
1 citations
,
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting mTORC1 activity with rapamycin increased both hair growth and pigmentation in human scalp hair follicles, suggesting a potential strategy for treating greying and hair loss.
1 citations
,
April 2021 in “Journal of Investigative Dermatology” This study found that Manganese PCA, Cinchona succirubra, and Leontopodium alpinum extracts may promote hair growth by enhancing VEGF secretion and activating the Wnt/b-catenin pathway in Human Hair Follicle Dermal Papilla Cells.
1 citations
,
October 2014 in “Skin Pharmacology and Physiology” This study found that osteopontin expression was significantly higher in alopecia areata lesions compared to healthy controls, suggesting it may play a role in the disease's pathogenesis.
1 citations
,
February 2012 in “The American Journal of Cosmetic Surgery” This case series provides anecdotal evidence that urinary bladder extracellular matrix may improve hair regrowth in donor scars and enhance hair follicle graft outcomes in hair restoration surgery.
May 2026 in “Frontiers in Cell and Developmental Biology” In this study, researchers suggest that hair follicle miniaturization in conditions like androgenetic alopecia may result from impaired conversion of quiescent stem cells to progenitor cells, influenced by the follicular niche, its collagen network, and various mechanical constraints.
May 2026 in “Iconic Research and Engineering Journals” This review concluded that polyherbal hair oils, using key medicinal plants, may offer a validated and sustainable alternative to synthetic cosmetics for hair and scalp health, with potential for industrial standardization and clinical use.
March 2026 in “Frontiers in Medicine” This study reported that two male patients with diffuse unpatterned alopecia exhibited donor-area involvement in both the vertex and occiput, challenging the assumption of occipital stability for hair transplantation, and showed partial improvement following treatment with oral finasteride and topical minoxidil.
December 2025 in “IP Indian Journal of Clinical and Experimental Dermatology” This review reports that the treatment of androgenetic alopecia is shifting from single therapies to personalized, multimodal approaches incorporating both traditional and emerging pharmacologics, regenerative strategies, nutraceuticals, cosmeceuticals, and device-based interventions, with combination regimens showing improved outcomes.
February 2025 in “Plastic and Aesthetic Research” In this study, after long-term observation of human scalp hair follicles over 16 years, the researchers found that a topical 5% minoxidil solution could stimulate hair regrowth after a period of dormancy, though with reduced growth rates and hair diameter.
This review article highlights the potential of various herbal treatments, such as Saw Palmetto and Ginseng, in promoting hair growth and managing alopecia, while emphasizing the necessity for more rigorous clinical trials.
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that a shampoo containing a 6-active ingredient complex increased β-Catenin production in human hair follicle dermal papilla cells to levels comparable to Finasteride, suggesting potential for promoting hair growth. It also showed good cleaning efficacy, volume, and shine in a sensorial study.
April 2021 in “Journal of Investigative Dermatology” This study identified a unique transcriptional signature in occipital hair follicles that may protect them from miniaturization in androgenetic alopecia, using an animal-free model to investigate gene roles.