Real-Time In Vivo Structure-Function Study of Scalp Hair Cycles: An Experimental Approach for Monitoring Living Hair Roots with a 20-Year Follow-Up

    February 2025 in “ Plastic and Aesthetic Research ”
    D. Van Neste
    Studysummary In this study, after long-term observation of human scalp hair follicles over 16 years, the researchers found that a topical 5% minoxidil solution could stimulate hair regrowth after a period of dormancy, though with reduced growth rates and hair diameter.
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    Research cited in this study 13

    1. The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma Experimental Dermatology · 2024
    2. A Segmental Approach to Scoring Hair Density from Global Images: Introducing the Scalp Coverage Scoring Method for Clinical Trials and Practice Nature Cell and Science · 2024
    3. A Practical Guide to Hair Graft Placement Using the Sharp Implanter Method Clinical, Cosmetic and Investigational Dermatology · 2023
    4. Exhaustive Analysis of Scalp Hair Regression: Subjective and Objective Perception from Initial Hair Loss to Severe Miniaturization and Drug-Induced Regrowth Plastic and Aesthetic Research · 2021
    5. Placebo-Controlled Dose-Effect Studies with Topical Minoxidil 2% or 5% in Male-Patterned Hair Loss Treated with Oral Finasteride Employing an Analytical and Exhaustive Study Protocol Skin Research and Technology · 2020
    6. Maintenance of Optimized Hair Growth from Viable Terminal Scalp Hair Follicles at Baseline with Oral Finasteride in Male Pattern Hair Loss and First Evidence of a Drug Dependency and a Post-Finasteride Rebound Effect Skin Research and Technology · 2019
    7. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    8. Exogen Hair Characterization in Human Scalp Skin Research and Technology · 2007
    9. Natural Scalp Hair Regression in Preclinical Stages of Male Androgenetic Alopecia and Its Reversal by Finasteride Skin Pharmacology and Physiology · 2006
    10. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    11. Does the Recipient Site Influence the Hair Growth Characteristics in Hair Transplantation? Dermatologic Surgery · 2002
    12. Contrast Enhanced Phototrichogram Pinpoints Scalp Hair Changes in Androgen Sensitive Areas of Male Androgenetic Alopecia Skin Research and Technology · 2002
    13. A Controlled Study of the Effects of RU58841, a Non-Steroidal Antiandrogen, on Human Hair Production by Balding Scalp Grafts Maintained on Testosterone-Conditioned Nude Mice British Journal of Dermatology · 1997

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    2. Safety and Efficacy of Trimax-360 Serum in Healthy Adult Subjects with Mild to Moderate Alopecia of the Scalp Journal of Cosmetic Dermatology · 2022
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