40 citations
,
July 2008 in “PROTEOMICS” This study introduced a bioengineered model that simulates acne's microenvironment in mice, enabling the exploration of host and P. acnes interactions and presenting a novel platform for anti-acne drug and vaccine screening.
40 citations
,
October 2002 in “Endocrinology” In this study, synthetic vitamin D3 analogs stimulated hair growth and formation of normal hair follicles in nude mice, unlike the natural form 1,25 dihydroxyvitamin D3.
40 citations
,
May 1987 in “The Lancet” Minoxidil helps some bald men, but most lose hair again when stopping.
39 citations
,
November 1987 in “Clinica Chimica Acta” Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
39 citations
,
November 1984 in “Journal of Cardiovascular Pharmacology” Minoxidil lowers blood pressure, increases heart rate, and improves blood flow in dogs.
39 citations
,
February 2024 in “Small” This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.
39 citations
,
June 2023 in “Advanced Materials” This review discusses the unique advantages and challenges of microneedle arrays for vaccine and immunotherapy delivery but reports no new clinical results.
39 citations
,
February 2021 in “Journal of The American Academy of Dermatology” In this study, low-dose oral minoxidil for hair loss was associated with infrequent systemic adverse effects, and only 1.7% of patients discontinued treatment due to these effects.
39 citations
,
May 2015 in “Advanced drug delivery reviews” This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs.
39 citations
,
January 2015 in “Journal of Electroanalytical Chemistry” In this study, a novel electrochemical sensor using a molecularly imprinted polymer was developed for the sensitive detection of minoxidil, successfully measuring its concentration in real samples.
39 citations
,
July 2013 in “Journal of dermatological science” This study found that microRNA levels in hair shafts were significantly decreased in scleroderma patients compared to normal subjects, suggesting they may serve as effective biomarkers.
39 citations
,
January 2011 in “Archives of Dermatology” This study found that the yellow dot pattern observed in dermoscopy of alopecia areata corresponds to inefficient follicular structures containing hair remnants, as corroborated by reflectance confocal microscopy and pathological findings.
39 citations
,
April 2010 in “International Journal of Pharmaceutics” This study found that using monoolein cubic phase nanoparticles with an entrapped hydroxypropyl β-cyclodextrin/minoxidil complex increased minoxidil skin permeation, but minoxidil retention in the skin was higher with a traditional solution.
39 citations
,
August 2005 in “Dermatologic surgery” This review describes the expanding medical uses of micropigmentation, including for vitiligo, burn scars, and nipple-areola reconstruction, and highlights safety concerns related to sterilization practices.
39 citations
,
January 1998 in “Dermatology” The authors concluded that milia, steatocystoma multiplex, and eruptive vellus hair cysts may be subtypes of multiple pilosebaceous cysts with overlapping histologic features.
38 citations
,
April 2018 in “Psychopharmacology/Psychopharmacologia” In this study, socially defeated mice showed increased alcohol consumption, and CRF-R1 antagonism selectively reduced drinking in these mice, suggesting a potential treatment target for stress-related alcohol use disorders.
38 citations
,
July 2021 in “ACS Nano” This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.
38 citations
,
July 2020 in “EMBO journal” In this study, researchers found that SIRT7 activates quiescent hair follicle stem cells to promote hair growth in mice by triggering the telogen-to-anagen cycle transition, with potential implications for age-related hair loss.
38 citations
,
June 2017 in “The Journal of Dermatology” This review synthesizes recent findings on the hair follicle stem cell niche and its complex interactions, exploring potential pathways for developing new hair growth therapies; it reports no new clinical results.
38 citations
,
June 2016 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrated that implanting μm-scale full-thickness columns of human skin tissue into immunodeficient mice restored key features of normal human skin, suggesting potential for human wound repair with minimal donor site morbidity.
38 citations
,
June 2005 in “Contact Dermatitis” This case report describes a patient with an allergic sensitization to minoxidil, indicating that such patients should pursue alternative therapies to treat androgenetic alopecia.
38 citations
,
June 2005 in “Matrix Biology” Minoxidil affects collagen-related genes, potentially helping treat fibrosis.
38 citations
,
January 1993 in “PubMed” This article discusses the impact of minoxidil on legitimizing scientific research in common baldness and reports no new clinical findings.
38 citations
,
October 1988 in “Clinics in Dermatology” Minoxidil can help grow hair and make hair follicles bigger, but it can also cause side effects.
37 citations
,
October 2013 in “PLoS ONE” This study provides new insights into the identification and expression patterns of miRNAs in wool follicles, which could improve understanding of wool follicle development in sheep.
37 citations
,
December 2018 in “Frontiers in Immunology” This study found that fibroin/gelatin and spidroin microparticles increased re-epithelialization rates and inhibited scar formation in mouse models of deep skin wounds.
37 citations
,
May 2016 in “JAAD case reports” This abstract describes monilethrix, an autosomal dominant genodermatosis with symptoms like hair fragility and keratosis pilaris, and does not report new experimental results.
37 citations
,
March 2009 in “Hair transplant forum international” This small study observed that infusing platelet rich plasma into the scalp reversed hair miniaturization and stimulated new hair growth in patients with androgenetic alopecia and alopecia areata over 8 months.
37 citations
,
May 2007 in “International Journal of Pharmaceutics” The study concluded that poly(propylene carbonate maleate) microspheres effectively encapsulated finasteride, achieving a biphasic release with prolonged drug release over 5-6 weeks in vitro.
37 citations
,
May 2002 in “PubMed” In this study, long-term use of finasteride did not negatively impact bone mineral density in men with benign prostatic hyperplasia over a 4-year period.