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Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

Scalp cooling and low-power light therapy show promise in reducing chemotherapy-induced hair loss but need more research.

Phytotherapeutic compounds and supplements can help manage Polycystic Ovarian Syndrome (PCOS).

Disrupted cholesterol production impairs hair follicle stem cells, leading to hair loss.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Shrinking of oil glands in the skin is a key sign of hair loss linked to TNF inhibitor drugs and may improve if the treatment is stopped.

Low testosterone in men is a risk factor for a specific heart rhythm issue, and testosterone treatment may help prevent it.

COVID-19 and hypopituitarism (reduced pituitary gland function) are linked, with the latter's related health issues potentially worsening COVID-19 outcomes, and COVID-19 possibly increasing risk for pituitary complications.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Certain gene variations might help protect against insulin resistance and glucose intolerance in people with Polycystic Ovary Syndrome.

Prenatally androgenized ewes can model increased hair diameter in women with PCOS.

Lower LDL-c levels predict higher COVID-19 mortality.

Adult female acne requires a comprehensive treatment approach, including medical options and lifestyle changes, with attention to psychological well-being.

Children with marasmus have more resting hair follicles and thinner, less pigmented hair, showing long-term malnutrition.

High-intensity interval training improves certain hormone levels and lipid profiles in women with PCOS.

Obesity is linked to various skin disorders, which can help with early diagnosis and prevention of long-term health issues.

Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.

PCOS may increase the risk of certain cancers.

PCOS is a common hormonal disorder in women, causing symptoms like acne and irregular periods, and is managed with medication and lifestyle changes.

Finasteride in male rats causes liver and metabolic issues in their offspring.

Polycystic ovary syndrome affects about 6-10% of women, with varying symptoms and the need for standardized global definitions.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.

High uric acid levels are more common in PCOS patients, especially those with androgenic PCOS, and are linked with increased cardiovascular risk and other metabolic issues.

The document concludes that managing PCOS requires a comprehensive approach, including lifestyle changes and medication, to improve symptoms and reduce health risks.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

Different parts of the body's fat tissue have unique cell types and characteristics, which could help treat chronic wounds.

Obesity is linked to more severe lower urinary tract symptoms.

Acne patients have higher levels of mTOR in their skin, which could be linked to future metabolic disease.