15 citations
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August 2017 in “Scientific Reports” This study found that young men with early-onset androgenetic alopecia have a worse glycolipid profile and hormone pattern similar to women's PCOS, suggesting a possible male PCOS-equivalent syndrome.
15 citations
,
October 2016 in “Journal of The European Academy of Dermatology and Venereology” This meta-analysis found that patients with androgenetic alopecia have significantly abnormal lipid profiles, which could contribute to the link between this condition and cardiovascular diseases.
14 citations
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August 2024 in “BMC Pregnancy and Childbirth” This meta-analysis reports that intrauterine autologous platelet-rich plasma infusion improved outcomes like endometrial thickness and clinical pregnancy rate in women with thin endometrium, but further large-scale trials are needed to confirm these findings.
14 citations
,
February 2017 in “Scientific Reports” Certain variations of the HDAC9 gene can increase or decrease stroke risk in the Chinese population.
13 citations
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June 2023 in “Frontiers in Pharmacology” This meta-analysis reports that trastuzumab deruxtecan is effective and has an acceptable safety profile for treating HER2-low or positive advanced breast cancer, although further research is recommended to support individualized treatment strategies.
13 citations
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August 2018 in “Life sciences” This meta-analysis suggests that combining Kang-ai injection with platinum-based chemotherapy may improve tumor response, performance status, immune functions, and reduce adverse reactions in patients with advanced non-small cell lung cancer.
10 citations
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January 2024 in “Burns & Trauma” This meta-analysis found that ADSC-Exo therapy can enhance healing in both general and diabetic wounds by promoting neovascularization, improving epithelization and collagen fiber deposition, and reducing scar formation, suggesting significant potential for clinical and research applications.
7 citations
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July 2025 in “International Journal of Dermatology” This meta-analysis found that patients with alopecia areata have significantly higher odds of also having immune-mediated diseases such as atopic dermatitis, autoimmune thyroiditis, inflammatory bowel disease, systemic lupus erythematosus, and vitiligo, suggesting a need for comprehensive screening and interdisciplinary management.
7 citations
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February 2022 in “Journal of Personalized Medicine” This meta-analysis found that platelet-rich plasma treatments significantly increased hair density in patients with androgenic alopecia, with results influenced by treatment frequency and patient age.
7 citations
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February 2022 in “Frontiers in Medicine” This study found that combining microneedling with PRP was more effective than microneedling alone for improving acne scars, with higher patient satisfaction and no significant increase in severe side effects.
7 citations
,
October 2017 in “Urologic Oncology: Seminars and Original Investigations” This meta-analysis found that male pattern baldness is associated with an increased risk of aggressive prostate cancer and benign prostatic hyperplasia.
6 citations
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October 2021 in “Biomedical Research and Therapy” This meta-analysis found that alopecia areata patients had significantly higher serum levels of IL-6 and TNF-α compared to healthy subjects, indicating a potential role of these cytokines in the condition's pathogenesis.
6 citations
,
December 2018 in “Medical principles and practice” This meta-analysis reported that individuals who frequently use hair dye or have used it for over 20 years have an increased risk of developing non-Hodgkin's lymphoma.
4 citations
,
October 2023 in “Journal of clinical medicine” This meta-analysis found that women with polycystic ovary syndrome have over a 2.5-fold higher risk of depression compared to healthy women.
4 citations
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March 2022 in “Journal of Infection” This study suggests that anti-androgen therapy may reduce the risk of SARS-CoV-2 infection and associated mortality, though results were not consistently supportive across all studies analyzed.
3 citations
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November 2024 in “Cancers” This meta-analysis involving over 3.7 million patients found that diabetes mellitus is associated with a reduced risk of developing prostate cancer, although significant heterogeneity exists among studies; however, a family history of prostate cancer was linked to a higher risk.
3 citations
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December 2021 in “Acta dermato-venereologica” This meta-analysis found that patients with androgenetic alopecia had a significantly higher prevalence of metabolic syndrome and poorer metabolic profiles compared to controls, especially among females, those with early onset, and individuals of African ethnicity.
3 citations
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August 2020 in “Urology Journal” This meta-analysis concluded that 5α-reductase inhibitors may increase the risk of mild depression, particularly with dutasteride, in patients treated for benign prostatic hyperplasia and androgenic alopecia.
2 citations
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September 2023 in “Health science reports” This meta-analysis found a strong association between metabolic syndrome and certain skin diseases, including psoriasis, hidradenitis suppurativa, androgenetic alopecia, and lichen planus, suggesting increased risk compared to the general population.
2 citations
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October 2021 in “Asian Journal of Andrology” This meta-analysis reported that the use of 5α-reductase inhibitors significantly increased the risk of postfinasteride syndrome-like adverse effects in men treated for benign prostatic hyperplasia or androgenetic alopecia.
2 citations
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January 2018 in “Australasian Medical Journal” This meta-analysis reviewed observational studies and found that androgenic alopecia, particularly in younger men, may be associated with an increased risk of heart disease.
1 citations
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September 2025 in “Frontiers in Immunology” This study reviewed the expression of chemokines in patients with alopecia areata, finding elevated Th1 and Th2 chemokine levels, suggesting a complex immune profile that may require broad immunomodulatory strategies to address the disease's underlying immune dysregulation.
1 citations
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March 2023 in “Frontiers in Medicine” This meta-analysis found that topical prostaglandin analogs could significantly improve hair length and density in patients with hair loss, compared to placebo, without notable safety differences.
May 2026 in “Journal of Clinical Medicine” This meta-analysis found a significantly higher prevalence of depressive symptoms in women with PCOS compared to a control group, with 42.11% versus 13.62% according to the BDI assessment, highlighting the need for psychiatric evaluation and support for women with this syndrome.
March 2026 in “Frontiers in Cell and Developmental Biology” This meta-analysis found that autologous cell-based therapies, especially stromal vascular fraction, significantly improved atrophic acne scars over control treatments, enhancing both clinical and patient-reported outcomes.
November 2025 in “Journal of Clinical Medicine” This study found that platelet-rich plasma may improve patient-reported outcomes for scar symptoms like pain and itching at six months, although no significant changes in scar appearance were observed at three months.
November 2025 in “Basic and Clinical Andrology” This systematic review and meta-analysis found that male first-degree relatives of women with PCOS have increased rates of metabolic issues, hormonal imbalances, and androgenic features compared to controls, suggesting a male equivalent of PCOS.
November 2025 in “Aesthetic Plastic Surgery” This meta-analysis found that while PRP therapy may result in higher patient satisfaction and better negative hair pull test results, it shows no clear advantage over minoxidil in terms of hair density or regrowth in androgenetic alopecia treatment.
October 2025 in “Journal of Cosmetic Dermatology” In this study, researchers found that type A botulinum toxin injections can reduce hypertrophic scars effectively, though more high-quality studies are needed to confirm the precision and stability of these therapeutic effects.
October 2025 in “Frontiers in Medicine” This meta-analysis found that the combination of topical minoxidil-finasteride was more effective than minoxidil alone in improving hair density, hair diameter, and global photographic assessment for male androgenetic alopecia, though larger standardized trials are needed to confirm long-term outcomes.